Improving the Outcome of Patients With Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome

Recurrent Erythema Multiforme/Stevens-Johnson Syndrome

“…One of the keys to management is to withdraw the offending drug or to treat the offending infection. 4,5 In a case-control study, Roujeau et al 6 found that the use of antibacterial sulfonamides, anticonvulsant agents, oxicam nonsteroidal anti-inflammatory drugs, allopurinol, chlormezanone, and, interestingly, corticosteroids is associated with large increases in the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis.…”

Intravenous Immunoglobulin Treatment for Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

“…However, a small series is of limited value, and the results should be confirmed by an appropriately designed randomized clinical trial. 4 Large numbers of patients would be necessary. As an example, we calculated that 400 patients should be included in such a trial to demonstrate a reduction in mortality from the current 23% to 12%.While we were exploring the feasibility and ethics of a double-blind, placebo-controlled randomized trial of IVIG therapy, we conducted the present monocenter pilot trial, a prospective noncomparative evaluation of the effect of IVIG therapy on the progression of the disease and mortality rate of patients with SJS and TEN.…”

Lamotrigine-induced toxic epidermal necrolysis in a young epileptic

“…The cornerstone of treatment for TEN is fluid replacement, nutritional support, surveillance and aggressive treatment for infection 18. It is managed as an acute emergency.…”