Improving the outcome of fractional CO2 laser resurfacing using a probiotic skin cream: Preliminary clinical evaluation

Abstract

As known, fractional CO resurfacing treatments are more effective than non-ablative ones against aging signs, but post-operative redness and swelling prolong the overall downtime requiring up to steroid administration in order to reduce these local systems. In the last years, an increasing interest has been focused on the possible use of probiotics for treating inflammatory and allergic conditions suggesting that they can exert profound beneficial effects on skin homeostasis. In this work, the Authors report their experience on fractional CO laser resurfacing and provide the results of a new post-operative topical treatment with an experimental cream containing probiotic-derived active principles potentially able to modulate the inflammatory reaction associated to laser-treatment. The cream containing DermaACB (CERABEST™) was administered post-operatively to 42 consecutive patients who were treated with fractional CO laser. All patients adopted the cream twice a day for 2 weeks. Grades were given according to outcome scale. The efficacy of the cream containing DermaACB was evaluated comparing the rate of post-operative signs vanishing with a control group of 20 patients topically treated with an antibiotic cream and a hyaluronic acid based cream. Results registered with the experimental treatment were good in 22 patients, moderate in 17, and poor in 3 cases. Patients using the study cream took an average time of 14.3 days for erythema resolution and 9.3 days for swelling vanishing. The post-operative administration of the cream containing DermaACB induces a quicker reduction of post-operative erythema and swelling when compared to a standard treatment.

The effects of recombinant human epidermal growth factor containing ointment on wound healing and post inflammatory hyperpigmentation prevention after fractional ablative skin resurfacing: A split‐face randomized controlled study

“…Several attempts have been addressed to decrease the degree of downtime and incidence of PIH, including using conservative energy settings and epidermal protection, strict sun avoidance, the use of preoperative and postoperative treatment regimens, such as early sunscreen application, topical or systemic steroid, moisturizer modified with antiinflammatory agents or probiotics, bleaching agents, and light emitting diode …”

“…1,4 Several attempts have been addressed to decrease the degree of downtime and incidence of PIH, including using conservative energy settings and epidermal protection, strict sun avoidance, the use of preoperative and postoperative treatment regimens, such as early sunscreen application, topical or systemic steroid, moisturizer modified with antiinflammatory agents or probiotics, bleaching agents, and light emitting diode. [5][6][7][8][9] Wound healing is a complex and dynamic process which can be divided simply into three phases, including inflammation, proliferation, and remodeling. 10 It is regulated by complex signaling networks, including numerous growth factors, cytokines, and chemokines.…”

The role of topical probiotics in skin conditions: A systematic review of animal and human studies and implications for future therapies

“…Numerous human studies have investigated the role of topical probiotics in various skin conditions . Skin conditions that have been investigated include atopic dermatitis, seborrhoeic dermatitis, acne and reactive skin.…”

Adverse effects of fractional laser

“…In case of persistent erythema, good therapeutic effects may be obtained after several procedures with a pulsed dyed laser (PDL) or intense pulse light (IPL) [9]. Interestingly, it may be possible to use a cream with probiotics in order to shorten the duration of post-procedural erythema and oedema [22].…”

“…W przypadku rumienia przetrwałego dobry efekt terapeutyczny można uzyskać po kilkukrotnych zabiegach laserem pulsacyjnym barwnikowym (pulsed dyed laser -PDL) lub impulsywnym źródłem światła (intense pulse light -IPL). [9] Ciekawa jest możliwość zastosowania kremu z probiotykiem, który skraca czas trwania pozabiegowego rumienia i obrzęku [22].…”