Improving the mechanical properties of strontium nitrate doped dicalcium phosphate cement nanoparticles for bone repair application

Fada, Rezvan; Shahgholi, Mohamad; Karimian, Majid

doi:10.1016/j.ceramint.2021.02.002

Cited by 26 publications

(7 citation statements)

References 25 publications

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“…The ASTM E9 standard is designed for compressive testing of metallic materials but also has been adopted for bone and bone-like materials compression tests. 23,24 Therefore, 7 mmdiameter cylindrical specimens in 14 mm height were prepared. The height of the specimens corresponded to the longitudinal axis of the osteons.…”

Section: Compression Testmentioning

confidence: 99%

Cortical Bone Mechanical Assessment via Free Water Relaxometry at 3 T

Talebi

Abbasi-Rad

Malekzadeh

et al. 2021

Magnetic Resonance Imaging

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Background: Investigation of cortical bone using magnetic resonance imaging is a developing field, which uses short/ultrashort echo time (TE) pulse sequences to quantify bone water content and to obtain indirect information about bone microstructure. Purpose: To improve the accuracy of the previously proposed technique of free water T 1 quantification and to seek the relationship between cortical bone free water T 1 and its mechanical competence. Study Type: Prospective. Subjects: Twenty samples of bovine tibia bone. Field Strength/Sequences: 3.0 T; ultra-fast two-dimensional gradient echo, Radio frequency-spoiled three-dimensional gradient echo. Assessment: Cortical bone free water T 1 was quantified via three different methods: inversion recovery (IR), variable flip angle (VFA), and variable repetition time (VTR). Signal-to-noise ratio was measured by dividing the signal of each segmented sample to background noise. Segmentation was done manually. The effect of noise on T 1 quantification was evaluated. Then, the samples were subjected to mechanical compression test to measure the toughness, yield stress, ultimate stress, and Young modulus. Statistical Tests: All the statistical analysis (Shapiro-Wilk, way analysis of variance, paired t test, Pearson correlation, and Bland-Altman plot) were done using SPSS. Results: Significant difference was found between T 1 quantification groups (P < 0.05). Average T 1 of each quantification method differed significantly after adding noise (P < 0.05). VFA-T 1 values significantly correlated with toughness (r = À0.68, P < 0.05), ultimate stress (r = À0.71, P < 0.05), and yield stress (r = À0.62, P < 0.05). No significant correlation was found between VTR-T 1 values and toughness (P = 0.07), ultimate stress (P = 0.47), yield stress (P = 0.30), and Young modulus (P = 0.39). Data Conclusion: Pore water T 1 value is associated with bone mechanical competence, and VFA method employing short-TE pulse sequence seems a superior technique to VTR method for this quantification. Level of Evidence: 2 Technical Efficacy: 1

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Section: Compression Testmentioning

confidence: 99%

Cortical Bone Mechanical Assessment via Free Water Relaxometry at 3 T

Talebi

Abbasi-Rad

Malekzadeh

et al. 2021

Magnetic Resonance Imaging

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“…Nanotechnology has evolved as cutting-edge technology in variety of sectors due to the unique, interesting, and improved properties of nanomaterials. Nanomaterials have at least one particle dimension in nanometer range (1–100 nm), and their properties are significantly different owing to higher surface area compared to bulk phase of the material. − The properties of nanoparticles (NPs) vary with morphology, composition, and purity which allows tunability of the properties according to application requirements. − Nanotechnology has made significant advancements in different sectors such as medical, , agricultural, electronic, − engineering, , computational, and materials science. ,− In the last few decades, biomedical applications such as drug delivery, anticancer activity, antimicrobial activity, topical gel activity, dental tissue engineering, bone repair, topical imaging, and SERS of NPs have gained significant attention employing their superior properties. − …”

Section: Introductionmentioning

confidence: 99%

“…7−9 Nanotechnology has made significant advancements in different sectors such as medical, 10,11 agricultural, electronic, 12−14 engineering, 15,16 computational, and materials science. 5,17−20 In the last few decades, biomedical applications such as drug delivery, 21 anticancer activity, 22 antimicrobial activity, 23 topical gel activity, 24 dental tissue engineering, 25 bone repair, 26 topical imaging, 27 and SERS of NPs have gained significant attention employing their superior properties. 28−32 The toxicity and biocompatibility of the NPs always remain the key challenges.…”

Section: Introductionmentioning

confidence: 99%

Recent Advancements in Plant- and Microbe-Mediated Synthesis of Metal and Metal Oxide Nanomaterials and Their Emerging Antimicrobial Applications

Rana

Pathak

Lim

et al. 2023

ACS Appl. Nano Mater.

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Antibiotic resistance against infections caused by microbes has emerged as a global challenge resulting in longer hospitalizations and higher medical cost and mortality. The excessive use of antibiotics has led to the swift progression of antibiotic resistance in bacterial strains. Metallic and metal oxide (M/MO) nanoparticles (NPs) have the potential to provide a pertinent alternative to antibiotics as they interact with the critical cellular organelles and biomolecules such as DNA, enzymes, ribosomes, and lysosomes. This affects the permeability of the cell membrane causing oxidative stress, gene expression, protein activation, and enzyme activation restricting the habitat of microbes. Further, NPs simultaneously target multiple biomolecules at once making them an efficient antibacterial agent against which microbes are unable to develop resistance easily, although the toxicity associated with the M/MO NPs still remains a key challenge for clinical uses. Green synthesis provides an efficient solution to reduce the toxic effects associated with these NPs as it does not use harsh chemicals and environment for the synthesis of NPs. In this work, we have provided a comprehensive review of the green synthesis of M/MO NPs using plants (roots, seeds, barks, flowers) and microbes (bacteria, fungi, algae). The yield of the NPs achieved from the green synthesis is lower than that of conventional methods and significant advancements have been made recently which are delineated in this review for different M/ MO NPs. Further, the mechanism of NP interaction with the microbes and their different antimicrobial applications have been discussed in detailed. The present review aims to provide a critical overview of the current state of the large-scale synthesis of the M/ MO NPs as well as their different antimicrobial activities.

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“…When incorporated into MBG, CP enhances its resemblance to natural bone, facilitating the controlled release of these ions and establishing an environment that supports the activity of bone cells and the formation of bone-like apatite. Throughout our experimental phase, HA has exhibited a range of favorable attributes, including compatibility with living tissues, absence of toxicity, ability to support bone growth, lack of immunogenicity, and serving as a fundamental component in the process of bone formation [37,38]. Furthermore, cell viability (MTT assay), and in vitro bioactivity were addressed in-depth to determine the optimum nanoparticle related to low cytotoxicity and enhancing the filling of the bone defects for these materials.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and In Vitro Bioactivity Studies of Silver-Doped, Cerium-Doped, and Silver–Cerium Co-Doped 80S Mesoporous Bioactive Glass Particles via Spray Pyrolysis

Taye,

Ningsih,

Shih

2023

Applied Sciences

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Researchers are concentrating on discovering reducing treatments for bacterial infections due to the worrisome and quick rise of drug-resistant microbial-related illnesses. Metallic ion doping and co-doping mesoporous bioactive glass (MBG) can defend against drug-resistant pathogens of Escherichia coli (E. coli) infection of wounds and solve the issues of bone deformities. In this study, un-doped MBG, silver-doped MBG (Ag-doped MBG), cerium-doped MBG (Ce-doped MBG), and silver–cerium co-doped MBG (Ag-Ce co-doped MBG) have been successfully synthesized via the spray pyrolysis method. In addition, various characterization techniques, including X-ray diffraction, field emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, and nitrogen adsorption–desorption, were used to investigate the phase compositions, surface morphologies, chemical compositions, inner structure morphologies, chemical bonds/functional groups, and specific surface areas, respectively. The antibacterial efficacy against E. coli was assessed using the colony count technique. All types of MBG with Ag, Ce, and Ag-Ce were effective against E. coli. Furthermore, when immersed in simulated body fluid, the MBGs formed hydroxyapatite and could be used to improve bone defects. Only 5.75 mol% Ag-doped MBG showed toxicity in the MTT assay test. According to our analysis, the 80S-Ag-Ce-MBG was the first Ag-Ce co-doped MBG.

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Improving the mechanical properties of strontium nitrate doped dicalcium phosphate cement nanoparticles for bone repair application

Cited by 26 publications

References 25 publications

Cortical Bone Mechanical Assessment via Free Water Relaxometry at 3 T

Cortical Bone Mechanical Assessment via Free Water Relaxometry at 3 T

Recent Advancements in Plant- and Microbe-Mediated Synthesis of Metal and Metal Oxide Nanomaterials and Their Emerging Antimicrobial Applications

Antibacterial and In Vitro Bioactivity Studies of Silver-Doped, Cerium-Doped, and Silver–Cerium Co-Doped 80S Mesoporous Bioactive Glass Particles via Spray Pyrolysis

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