. A model-driven approach to multidisciplinary collaborative simulation for virtual product development. Advanced Engineering Informatics, Elsevier, 2010, 24 (2) Abstract:The design and development of complex artifacts and systems is shifting towards a distributed and collaborative paradigm. The simulation environments for such a paradigm, therefore, need to take into account the cooperation between design teams, i.e. supporting multidisciplinary simulation in a distributed environment. However, current simulation tools cannot fulfil this requirement as they have been developed to solve the specific problems from different disciplines. Although it's already possible to per-form multidisciplinary simulations by using several tools together, it is very difficult to implement it when these tools are distributed on the Internet. A solution which can support the integration of distributed simulation models at run-time is presented, involving a computational infrastructure and a high-level modelling approach. Specifically, the infrastructure is constructed by a novel combination of two distributed computing techniques to implement the synchronization of distributed models, as well as to ensure the interoperability at run-time. In addition, a model-driven approach is developed to bridge the high-level model of a simulation system and the infrastructure which implements this model. The solution is evaluated by making a comparison with other approaches, as well as by developing a prototype tool. It's shown in the evaluation that (1) it is viable to develop multidisciplinary simulations in a distributed environment using this solution; (2) the model-driven approach allows designers to focus only on the high-level structure of a design without getting concerned with the details of the infrastructure.