Improving the durability of resin-dentin bonds with an antibacterial monomer MDPB

Abstract

The 12-methacryloxydodecylpyridium bromide (MDPB) has been reported to act as a matrix metalloprotease (MMP) inhibitor. In this study, the effects of application of MDPB on resin-dentin bonds were evaluated. The resin-dentin bonded specimens were prepared with a commercial MDPB-containing self-etching primer or a self-etching primer without MDPB, and stored 24 h or 1 year. Surfaces were pretreated with chlorhexidine or MDPB-containing cavity disinfectant. Additionally, we compared the degradation patterns between the two self-etching adhesives and etch and rinse system. Water tree formations were observed as the typical morphological phase of the two tested self-etching adhesives for both 24 h and 1 year groups. The degradation phase of collagen network depletion was observed in the adhesive interface of the etch-and-rinse system in the 1 year group. Pretreatment with chlorhexidine did not prevent bond strength reduction after 1 year. The cavity disinfectant improved the bond durability for the self-etching adhesive.

Chemical interaction of 4-META with enamel in resin-enamel bonds

“…A gel layer, which is a chemical reaction layer, can be observed using TEM in the upper part of the hybrid layer at the resin-dentin interface formed by a bonding resin system containing polycarboxylic acid [11][12][13] . However, because the layer is fragmentarily formed on the upper part of the hybrid layer, it is difficult to analyze the spots on the chemical reaction layer from the sagittal plane.…”

“…Some transmission electron microscopy (TEM) studies have identified the deposition of an amorphous phase on top of the hybrid layer created by the resin adhesive or resin-modified glass ionomer cement. This amorphous phase contains a polyalkenoic acid co-polymer component owing to the precipitation of polycarboxylate salts on the dentin surface, which yields calcium through a chemical reaction [11][12][13] . Although such studies have provided morphological evidence of bonding around the adhesive joint, the exact mechanism of the chemical reaction remains unclear.…”

Novel Bioactive and Therapeutic Root Canal Sealers with Antibacterial and Remineralization Properties

“…One explanation of the improved or maintained sealing and bonding properties of QAMs containing root canal sealers could be through their ability to inhibit host-derived and bacteria-derived matrix metalloproteinases (MMPs), which are known to accelerate the degradation of the sealer dentin bond [83][84][85]. Previous studies have demonstrated the ability of MDPB to inhibit soluble MMPs and matrix-bound dentin MMPs [83]. Indeed, another study showed the ability of DMADDM to achieve 90% inhibition of MMPs [84].…”

Dentin bond strength evaluation between a conventional and universal adhesive using etch-and-rinse strategy

“…Since the introduction of the adhesive systems, over 50 years ago, the union interface to dentin remains the weakest link in restorative treatment [1][2][3][4] . Although many studies have shown excellent short-term and immediate adhesion effectiveness 5,6 , the durability and stability of the adhesive interface on dentin remain questionable 7,8 due to its inherent characteristics.…”