Improving the care of patients with cystic fibrosis (CF)

Abstract

BackgroundThe West Midlands Adult Cystic Fibrosis (CF) Centre based at Birmingham Heartlands Hospital provides care for adults with CF in the West Midlands. People with CF are prone to pulmonary exacerbations, which often require inpatient admission for intravenous antibiotics. We observed that the admission process was efficient during working hours (9:00–17:00, Monday–Friday) when the CF team are routinely available, but out-of-working hours, there were delays in these patients being clerked and receiving their first antibiotic dose. We were concerned that this was resulting in quality and potential safety issues by causing delays in starting treatment and prolonging hospital inpatient stays. We therefore undertook a quality improvement project (QIP) aimed at addressing these issues. An initial survey showed median time to clerk of 5 hours, with 60% of patients missing their first dose of antibiotics and mean length of stay of 16 days.MethodsWe applied the Plan-Do-Study-Act (PDSA) cycle approach, with the first PDSA cycle involving raising awareness of the issue through education to doctors, nurses and patients.ResultsThis led to a reduction of median time to clerk from 5 to 2 hours with 23% of patients missing their first antibiotic dose and mean length of stay reducing to 14 days. The second cycle involved introducing an admissions checklist and displaying education posters around the hospital, resulting in median time to clerk remaining at 2 hours but only 20% of patients missing their first antibiotic dose and the mean length of stay remaining at 14 days.ConclusionThis QIP has improved the out-of-hours admissions process for adults with CF in our centre. We plan to review the longer term effects of the project including sustainability, effects on clinical outcomes and patient satisfaction.

Harmonizing Outcomes for Genomic Medicine: Comparison of eMERGE Outcomes to ClinGen Outcome/Intervention Pairs

“…The outcomes are compared across sites and opportunities to improve care are identified, followed by implementation at the centers. This approach, which is also being used in other settings, has resulted in a dramatic improvement in multiple outcomes of interest for patients with CF [ 26 ]. The hope is that similar improvements in care could be realized across the many conditions for which genomic information can be used to inform care.…”

Harmonizing Outcomes for Genomic Medicine: Comparison of eMERGE Outcomes to ClinGen Outcome/Intervention Pairs

“…The outcomes are compared across sites and opportunities to improve care are identified, followed by implementation at the centers. This approach, which is also being used in other settings, has resulted in dramatic improvement in multiple outcomes of interest for patients with CF [26]. The hope is that similar improvements in care could be realized across the many conditions for which genomic information can be used to inform care.…”

Quality improvement and rapid PDSA cycles to maintain routine surveillance of pulmonary pathogens during the COVID-19 pandemic in a pediatric cystic fibrosis clinic

“…The need for quick, systematic changes in a rapidly developing pandemic lead the clinic to utilize Plan-Do-Study-Act (PDSA) cycles. This is a four-step model that has gained wide acceptance and utilization in healthcare quality improvement (QI) (Christoff, 2018;Khan, 2017;Taylor, 2014). This CF center has a QI team well versed in using this model as a guide for QI projects.…”