Improving the blood compatibility of polyurethane using carbon nanotubes as fillers and its implications to cardiovascular surgery

Meng, Jie; Hua, Ke; Xu, Haiyan; Li, Song; Wang, Chunyang; Xie, Sishen

doi:10.1002/jbm.a.30315

Cited by 90 publications

(66 citation statements)

References 15 publications

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“…Some researches have focused more on the applicability of PU/CNT composites to different fields such as biomedicine [17][18][19], adding benefit of the unique properties of CNT, while some others have focused more on the materials science point of view [20]. While in some works the research was focused on understanding the effects of the addition of CNT to a polyurethane matrix through melt blending [21] or solvent mixing [22][23][24], in some others it has been tried to benefit from the polyurethanes chemistry to prepare grafted nanotubes hybrids which were further polymerised in-situ with the aim of creating CNT cross-linked networks 4 [25][26][27][28][29][30], or to functionalise the nanotubes and then solvent mix them with the polyurethanes to compare the effect of different nanotubes treatments [31,32].…”

Section: Introductionmentioning

confidence: 99%

Influence of hard segment content and nature on polyurethane/multiwalled carbon nanotube composites

Fernández-d’Arlas

Khan

Rueda

et al. 2011

Composites Science and Technology

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. carbon nanotubes percolative network formation seemed to be crucial for obtaining significant reinforcement, being observed at this stage, a reduction of ductility, phenomena which is related to an increase on hard domains interconnections by MWCNT. The hard to soft segment ratio into PU plays a crucial role on determining the stress transfer to MWCNT. In addition, PU hard domains nature has important effect on nanotubes reinforcing character, this fact being related to the different PU intrinsic morphologies as well as different PU-MWCNT interactions.

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Section: Introductionmentioning

confidence: 99%

Influence of hard segment content and nature on polyurethane/multiwalled carbon nanotube composites

Fernández-d’Arlas

Khan

Rueda

et al. 2011

Composites Science and Technology

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“…The distance between each layer of graphite sheet in MWCNT is approximately 0.42 nm. CNTs are used in various biomedical applications like biosensors, diagnostic agents to visualize cancer cells, etc, and recently 40,41 Meng et al 42 prepared a multiwalled carbon nanotube-polyurethane nanocomposite (MWCNT-PU) via controlled coprecipitation. Platelet adhesion was determined using SEM, and platelet activation caused by PU and MWCNT-PU was investigated through flow cytometric analysis.…”

Section: Nanocomposites To Improve Hemocompatibility Of Graftmentioning

confidence: 99%

Multifaceted prospects of nanocomposites for cardiovascular grafts and stents

Vellayappan¹,

Balaji²,

Subramanian³

et al. 2015

IJN

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Cardiovascular disease is the leading cause of death across the globe. The use of synthetic materials is indispensable in the treatment of cardiovascular disease. Major drawbacks related to the use of biomaterials are their mechanical properties and biocompatibility, and these have to be circumvented before promoting the material to the market or clinical setting. Revolutionary advancements in nanotechnology have introduced a novel class of materials called nanocomposites which have superior properties for biomedical applications. Recently, there has been a widespread recognition of the nanocomposites utilizing polyhedral oligomeric silsesquioxane, bacterial cellulose, silk fibroin, iron oxide magnetic nanoparticles, and carbon nanotubes in cardiovascular grafts and stents. The unique characteristics of these nanocomposites have led to the development of a wide range of nanostructured copolymers with appreciably enhanced properties, such as improved mechanical, chemical, and physical characteristics suitable for cardiovascular implants. The incorporation of advanced nanocomposite materials in cardiovascular grafts and stents improves hemocompatibility, enhances antithrombogenicity, improves mechanical and surface properties, and decreases the microbial response to the cardiovascular implants. A thorough attempt is made to summarize the various applications of nanocomposites for cardiovascular graft and stent applications. This review will highlight the recent advances in nanocomposites and also address the need of future research in promoting nanocomposites as plausible candidates in a campaign against cardiovascular disease.

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“…Polyurethane (PU) has been reported in a variety of processing biomedical devices such as artificial hearts [1,2], cardiovascular biomaterials [3][4][5], and scaffolds [6,7] for over four decades. This synthetic polymer contains soft and hard segments which contributes to different degree of micro-phase separation, consequently affects its physical and mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

Hemocompatibility Evaluation of Polyurethane Film with Surface-Grafted Sugar- Based Amphipathic Compounds

Xin¹,

Du²,

Wang³

et al. 2017

J Anal Bioanal Tech

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Sugar-based amphipathic compounds (BA-CnAG) were successfully prepared. Polyurethane (PU) was grafted with glycidyl methacrylate (GMA) by the means of UV irradiation, and further modified with the BA-CnAG based on the ring opening of the epoxy groups. The surface graft polymerization was confirmed by ATR-FTIR and XPS. Water contact angle, protein adsorption, and platelet adhesion measurements were used to evaluate the hydrophilicity and hemocompatibility of the films. The results demonstrated that amphiphilic surfactant-containing polymer surfaces presented protein-resistant behavior and anti-platelet adhesion after functionalization with BA-CnAG. Besides, the hemocompatibility of the modified surface deteriorated as the length of hydrophobic chain of BA-CnAG increased. glycidyl methacrylate (GMA) were obtained from Shanghai Aladdin Chemicals (China). Benzophenone (BP) was supplied by Peking Ruichen Chemicals (China). Bovine serum albumin (BSA), sodium dodecyl sulfate (SDS) and phosphate buffered solution (PBS, 0.01 mol/L, pH=7.4) were provided by Dingguo Bio-technology (China). Micro BCATM protein assay reagent kits were purchased from Boster Biological Technology (AR1110, China). The platelet-rich plasma (PRP) was obtained from the fresh rabbit blood by centrifugation at 1000 rpm for 15 min. The other solvents and reagents were AR grade chemicals and used without further purification. Preparation and characterization of sugar-based amphipathic compoundsSynthesis of Boc-Asp: To a solution of Asp (10 mmol) in acetone/ ultrapure water (10:1, 44 mL), was added triethylamine (20 mmol), and the resulting solution was stirred in an ice-water bath. (B OC ) 2 O (11 mmol) was added dropwise, stirred for 3 h. The solution was concentrated under reduced pressure, diluted with H 2 O (20 mL), Scheme 2: Schematics of the PU surface modified with sugar-based amphipathic compounds.

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Improving the blood compatibility of polyurethane using carbon nanotubes as fillers and its implications to cardiovascular surgery

Cited by 90 publications

References 15 publications

Influence of hard segment content and nature on polyurethane/multiwalled carbon nanotube composites

Influence of hard segment content and nature on polyurethane/multiwalled carbon nanotube composites

Multifaceted prospects of nanocomposites for cardiovascular grafts and stents

Hemocompatibility Evaluation of Polyurethane Film with Surface-Grafted Sugar- Based Amphipathic Compounds

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