Improving the blood clearance time of 125I labeled Dex-g-PMAGGCONHTyr by copolymerization

Synthesis of poly(ethylene glycol)-b-poly(N-(2-hydroxypropyl) methacrylamide) block copolymers with well-defined structures and their influence on in vivo circulation and biodistribution

“…Therefore, from the viewpoint of efficient transportation of anticancer drug, the copolymers with slight negative charge such as P5H30M5 are the best candidates as drug conjugates with long circulation time and optimal biodistribution. Furthermore, compared with those PEG or HPMA modied Dexg-PMAGGCONHTyr copolymers, 18 PEG-b-PHPMA copolymers in this work showed a longer circulation time and better biodistribution patterns.…”

“…13 Polymer-drug conjugates have been widely studied for three decades as a potential solution to overcome the limitations of current chemotherapy. 3,14 The typical polymers include poly-(ethylene glycol) (PEG), 15 poly(N-(2-hydroxypropyl) methacrylamide) (PHPMA), 16 dextran, 17,18 polyglutamate, 19 etc. PEG has been widely studied due to its non-toxic, non-immunogenic characteristics, and especially the approval by the Food and Drug Administration (FDA) for clinical application.…”

Synthesis and Functions of Well-defined Polymer-drug Conjugates as Efficient Nanocarriers for Intravesical Chemotherapy of Bladder Cancera

“…However, to the best of our knowledge, few researchers have focused on the potential application of water‐soluble polymer‐drug conjugates in the instilled chemotherapy, even though these systems have showed great potentials to overcome multidrug resistance . Poly(ethylene glycol) (PEG) and poly[ N ‐(2‐hydroxy) methylacrylamide] (PHPMA) have been widely used to reduce the organ uptake and to prolong the in vivo circulation half‐life of various drug carriers . The combination of these two kinds of polymers have exhibited prominent performance in these two aspects as shown in our previous work .…”

Polymer–Doxorubicin Conjugate Micelles Based on Poly(ethylene glycol) and Poly(N-(2-hydroxypropyl) methacrylamide): Effect of Negative Charge and Molecular Weight on Biodistribution and Blood Clearance

“…Besides, compared with the pure PHPMA- b -PLMA copolymers, a continuous increase of tumor accumulation could be found with the increase of PEGylation degree for the PEGylated copolymers . Wang and co-workers report that the introduction of PEG and PHPMA into the dextran graft copolymers can increase the blood pool concentration of dextran graft poly­( N -methacryloylglycylglycine)-tyrosine conjugates (Dex- g -PMAGGCONHTyr) …”