Improving the Assessment of Risk Factors Relevant to Potential Carcinogenicity of Gene Therapies: A Consensus Article

Klapwijk, Jan C.; Del Rio Espinola, Alberto; Libertini, Silvana; Collin, Philippe; Fellows, Mick D.; Jobling, Susan; Lynch, Anthony M.; Martus, HansJoerg; Vickers, Catherine; Zeller, Andreas; Biasco, Luca; Brugman, Martijn H.; Bushmann, Frederic D.; Cathomen, Toni; Ertl, Hildegrund C.J.; Gabriel, Richard; Gao, Guangping; Jadlowsky, Julie K.; Kimber, Ian; Lanz, Thomas A.; Levine, Bruce L.; Micklethwaite, Kenneth P.; Onodera, Masafumi; Pizzurro, Daniella M.; Reed, Simon; Rothe, Michael; Sabatino, Denise E.; Salk, Jesse J.; Schambach, Axel; Themis, Michael; Yuan, Jing

doi:10.1089/hum.2024.033

Human Gene Therapy

2024

DOI: 10.1089/hum.2024.033

|View full text |Cite

Improving the Assessment of Risk Factors Relevant to Potential Carcinogenicity of Gene Therapies: A Consensus Article

Jan C. Klapwijk,

Alberto Del Rio Espinola,

Silvana Libertini

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 103 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Genotoxicity evaluation of gene therapies: A report from the International Workshop on Genotoxicity Testing (IWGT) 2022

Libertini,

Jadlowsky,

Lanz

et al. 2024

Environ and Mol Mutagen

View full text Add to dashboard Cite

At the 8th International Workshop on Genotoxicity Testing meeting in Ottawa, in August 2022, a plenary session was dedicated to the genotoxicity risk evaluation of gene therapies, including insertional oncogenesis and off‐target genome editing. This brief communication summarizes the topics of discussion and the main insights from the speakers. Common themes included recommendations to conduct tailored risk assessments based on a weight‐of‐evidence approach, to promote data sharing, transparency, and cooperation between stakeholders, and to develop state‐of‐the‐art validated tests relevant to clinical scenarios.

show abstract

Genotoxicity evaluation of gene therapies: A report from the International Workshop on Genotoxicity Testing (IWGT) 2022

Libertini,

Jadlowsky,

Lanz

et al. 2024

Environ and Mol Mutagen

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Improving the Assessment of Risk Factors Relevant to Potential Carcinogenicity of Gene Therapies: A Consensus Article

Cited by 1 publication

References 103 publications

Genotoxicity evaluation of gene therapies: A report from the International Workshop on Genotoxicity Testing (IWGT) 2022

Genotoxicity evaluation of gene therapies: A report from the International Workshop on Genotoxicity Testing (IWGT) 2022

Contact Info

Product

Resources

About