Improving the analytical flexibility of thermal desorption in determining unknown VOC samples by using re-collection

Duan, Zhenhan; Kjeldsen, Peter; Scheutz, Charlotte

doi:10.1016/j.scitotenv.2020.144692

Cited by 7 publications

(4 citation statements)

References 29 publications

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“…Considering the time needed (per sample/patient) for transferring the breath from the bag to the TD tube, it would translate from 20 to 5 min. Nevertheless, for untargeted studies, 5 L sampling bags might be preferred to collect as many volatile metabolites as possible, and to quantitatively recollect the flow of analytes split during the cold‐trap desorption stage [ 31 ]. To prove the representativeness of the sample between the first desorption (on platform 1) and the second desorption (1 recollection, on platform 2), the efficiency of recollection was tested on the target analytes.…”

Section: Resultsmentioning

confidence: 99%

Comprehensive two‐dimensional gas chromatographic platforms comparison for exhaled breath metabolites analysis

Zanella

Henin

Mascrez

et al. 2022

J of Separation Science

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The high potential of exhaled breath for disease diagnosis has been highlighted in numerous studies. However, exhaled breath analysis is suffering from a lack of standardized sampling and analysis procedures, impacting the robustness of inter-laboratory results, and thus hampering proper external validation. The aim of this work was to verify compliance and validate the performance of two different comprehensive two-dimensional gas chromatography coupled to mass spectrometry platforms in different laboratories by monitoring probe metabolites in exhaled breath following the Peppermint Initiative guidelines. An initial assessment of the exhaled breath sampling conditions was performed, selecting the most suitable sampling bag material and volume. Then, a single sampling was performed using Tedlar bags, followed by the trapping of the volatile organic compounds into thermal desorption tubes for the subsequent analysis using two different analytical platforms. The thermal desorption tubes were first analyzed by a (cryogenically modulated) comprehensive two-dimensional gas chromatography system coupled to high-resolution time-of-flight mass spectrometry. The desorption was performed in split mode and the split part was recollected in the same tube and further analyzed by a different (flow modulated) comprehensive two-dimensional gas chromatography system with a parallel detection, specifically using a quadrupole mass spectrometer and a vacuum ultraviolet detector. Both the comprehensive two-dimensional gas chromatography platforms enabled the longitudinal tracking of the peppermint oil metabolites in exhaled breath. The increased sensitivity of comprehensive two-dimensional gas chromatography enabled to successfully monitor over a 6.5 h period a total of 10

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Section: Resultsmentioning

confidence: 99%

Comprehensive two‐dimensional gas chromatographic platforms comparison for exhaled breath metabolites analysis

Zanella

Henin

Mascrez

et al. 2022

J of Separation Science

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“…where ∆F is the change in the sensor oscillation frequency after the coating deposition, MHz; F 0 is the base oscillation frequency, MHz; 2.27•10 −6 is a calibration constant of piezoelectric quartz resonator at normal conditions, cm 2 /g; A is the area of Ag electrodes, cm 2 . The film mass deposited on electrodes was up to 20 µg/cm 2 .…”

Section: Device and Sensor Array Characteristicsmentioning

confidence: 99%

“…Beyond the traditional method used in search of close or similar samples, based on data distribution in space, more detailed information is required in order to estimate a sample's composition, and the presence of particular compounds and markers within it. Such a task can be solved by means of traditional analytical chemistry methods, such as the standard additive method, the internal standard method, or via sensor array training and the identification of specific responses to the calibration function [2][3][4][5][6]. However, due to the instability and variability of gaseous mixture compositions (especially the ones emitted from samples of complex natures), the training method with the cross-selectivity of sensors is inaccurate for individual substances.…”

Section: Introductionmentioning

confidence: 99%

The New Approach to a Pattern Recognition of Volatile Compounds: The Inflammation Markers in Nasal Mucus Swabs from Calves Using the Gas Sensor Array

et al. 2021

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This paper discusses the application of two approaches (direct and inverse) to the identification of volatile substances by means of a gas sensor array in a headspace over nasal mucus swab samples taken from calves with differing degrees of respiratory damage. We propose a unique method to visualize sensor array data for quality analysis, based on the spectra of cross mass sensitivity parameters. The traditional method, which requires an initial sensor array trained on the vapors of the individual substances (database accumulation)—with their further identification in the analyzed bio-samples through the comparison of the analysis results to the database—has shown unsatisfactory performance. The proposed inverse approach is more informative for the pattern recognition of volatile substances in the headspace of mucus samples. The projection of the calculated parameters of the sensor array for individual substances in the principal component space, acquired while processing the sensor array output from nasal swab samples, has allowed us to divide animals into groups according to the clinical diagnosis of their lung condition (healthy respiratory system, bronchitis, or bronchopneumonia). The substances detected in the gas phase of the nasal swab samples (cyclohexanone, butanone-2,4-methyl-2-pentanone) were correlated with the clinical state of the animals, and were consistent with the reference data on disease markers in exhaled air established for destructive organism processes.

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“…The analytical method was able to quantify 92 VOCs with detection limits between 0.01 and 2 ng for most compounds, and the precision and accuracy were generally within 20%. More information regarding the analytical method is available in Duan et al (2021a).…”

Section: Trace Gas Sample Analysismentioning

confidence: 99%

Mitigation of methane and trace gas emissions through a large-scale active biofilter system at Glatved landfill, Denmark

et al. 2021

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Improving the analytical flexibility of thermal desorption in determining unknown VOC samples by using re-collection

Cited by 7 publications

References 29 publications

Comprehensive two‐dimensional gas chromatographic platforms comparison for exhaled breath metabolites analysis

Comprehensive two‐dimensional gas chromatographic platforms comparison for exhaled breath metabolites analysis

The New Approach to a Pattern Recognition of Volatile Compounds: The Inflammation Markers in Nasal Mucus Swabs from Calves Using the Gas Sensor Array

Mitigation of methane and trace gas emissions through a large-scale active biofilter system at Glatved landfill, Denmark

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