Improving Tableting Performance of Lactose Monohydrate by Fluid-Bed Melt Granulation Co-Processing

Medarević, Djordje; Djuriš, Jelena; Krkobabić, Mirjana; Ibrić, Svetlana

doi:10.3390/pharmaceutics13122165

Cited by 7 publications

(4 citation statements)

References 20 publications

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“…The results were in accordance with other studies [ 192 , 193 ]. The applications of other modifiers were summarized in Table 5 [ 36 , 98 , 139 , 141 , 165 , 172 , 178 , 194 , 195 , 196 , 197 , 198 , 199 , 200 , 201 , 202 , 203 ].…”

Section: Othersmentioning

confidence: 99%

Surface Modifiers on Composite Particles for Direct Compaction

Chen

Liu²,

Zhu³

et al. 2022

Pharmaceutics

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Direct compaction (DC) is considered to be the most effective method of tablet production. However, only a small number of the active pharmaceutical ingredients (APIs) can be successfully manufactured into tablets using DC since most APIs lack adequate functional properties to meet DC requirements. The use of suitable modifiers and appropriate co-processing technologies can provide a promising approach for the preparation of composite particles with high functional properties. The purpose of this review is to provide an overview and classification of different modifiers and their multiple combinations that may improve API tableting properties or prepare composite excipients with appropriate co-processed technology, as well as discuss the corresponding modification mechanism. Moreover, it provides solutions for selecting appropriate modifiers and co-processing technologies to prepare composite particles with improved properties.

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Section: Othersmentioning

confidence: 99%

Surface Modifiers on Composite Particles for Direct Compaction

Chen

Liu²,

Zhu³

et al. 2022

Pharmaceutics

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“…Полоксамер 188 широко используется в масштабном производстве клеточных культур млекопитающих и в культивировании клеточных культур в биореакторах [58][59][60][61][62] как защитный наполнитель для повы-шения продуктивности клеточной биомассы на встря хиваемых культурах и уменьшения клеточной адгезии на стационарных культурах. Были предложены два механизма, объясняющие защитное действие полоксамера 188 на клетки.…”

Section: общая характеристика и возможности применения блок-сополимер...unclassified

Block Copolymers of Ethylene Oxide and Propylene Oxide: Prospects for Medical and Pharmaceutical Application in Russia

Bakhrushina,

Pyzhov,

Sakharova

et al. 2023

Vedomosti Nauchnogo tsentra ekspertizy sredstv meditsinskogo pr

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Block copolymers of ethylene oxide and propylene oxide (EO/PO block copolymers) are polymeric non-ionic surfactants with a high hydrophilic–lipophilic balance also referred to as pluronics, poloxamers, or proxanols. These compounds are among the most demanded modern excipients for the production of medicines. EO/PO block copolymers are used both in the production of traditional (liquid, semi-solid, and solid) dosage forms and as part of targeted delivery systems. The extensive application of EO/PO block copolymers is due to the diverse array of their properties, including not only solubilising, emulsifying, gelling, and other effects but also thermoreversibility, which is essential for developing in situ delivery systems and 3D printing technologies.The aim of the study was to evaluate the potential of EO/PO block copolymers for medicinal use and to assess the range of medicinal products approved in the Russian Federation that contain EO/PO block copolymers.This review presents an analysis of the register of poloxamer-containing medicines approved in the Russian Federation, a list of the largest manufacturers of EO/PO block copolymers in the world, and a study of the possibility to use copolymers for medical purposes. Currently, there are more than 10 chemical manufacturers producing EO/PO block copolymers for the pharmaceutical, biotechnology, and other industries around the world. EO/PO block copolymers are included in more than 60 medicinal products present in the Russian pharmaceutical market; this observation indicates the need to phase out the import of poloxamers.

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“…Table 3 presents the advantages and limitations of each co-processing technique. 42,[45][46][47][48]…”

Section: Co-processed Excipientsmentioning

confidence: 99%

Application of co-processed excipients for developing fast disintegrating tablets: A review

Jain¹,

Kaur²,

Rathi³

et al. 2023

Polim. Med.

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The introduction of tablet dosage forms has brought a revolution in the pharmaceutical drug delivery system. Different forms of tablets have been developed based on the target site, the onset of action, and therapeutic drug delivery methods. Fast-disintegrating tablets (FDTs) are the most promising pharmaceutical dosage form, especially for pediatric and geriatric patients having difficulty swallowing. The key feature of FDTs is quick drug release soon after their administration through the oral cavity. With innovations in the formulation of FDTs, the demand for excipients with better functionalities, particularly in terms of flow and compression characteristics, has increased. Co-processed excipients are a mixture of 2 or more conventional excipients that provides significant benefits over the individual excipients while minimizing their shortcomings. Such multifunctional co-processed excipients minimize the number of excipients that are to be incorporated into tablets during the manufacturing process. The present review discusses FTDs formulated from co-processed excipients, their manufacturing techniques, and the latest research, patents and commercially available co-processed FDTs.

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Improving Tableting Performance of Lactose Monohydrate by Fluid-Bed Melt Granulation Co-Processing

Cited by 7 publications

References 20 publications

Surface Modifiers on Composite Particles for Direct Compaction

Surface Modifiers on Composite Particles for Direct Compaction

Block Copolymers of Ethylene Oxide and Propylene Oxide: Prospects for Medical and Pharmaceutical Application in Russia

Application of co-processed excipients for developing fast disintegrating tablets: A review

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