Improving survivability from blast injury: ‘shifting the goalposts’ and the need for interdisciplinary research

Péarce, Andrew; Clasper, Jon

doi:10.1136/jramc-2018-000968

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…White emphasized the need for closer collaboration especially between physicists and biologists-although he makes note of critical additional collaboration with engineers, architects, and physicians-for each expert to bring their discipline to bear on this problem. The need for integration continues to be echoed by experts, where only through collaborative efforts between blast physicists and biologists (198), military-relevant and academic researchers (199), and "surgical engineers" (200) and that there can be progress by learning from clinical cases that elucidate what symptoms require mimicking in animal studies (199). The blast neuroscience or neuroendocrinology investigator, then, should seek collaboration and ongoing consultation with the appropriate experts who can immensely improve the quality of the research effort.…”

Section: Preclinical Modeling Of Blast For the Study Of Sex Differencmentioning

confidence: 99%

Sex as a Biological Variable in Preclinical Modeling of Blast-Related Traumatic Brain Injury

McCabe

Tucker

2020

Front. Neurol.

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Approaches to furthering our understanding of the bioeffects, behavioral changes, and treatment options following exposure to blast are a worldwide priority. Of particular need is a more concerted effort to employ animal models to determine possible sex differences, which have been reported in the clinical literature. In this review, clinical and preclinical reports concerning blast injury effects are summarized in relation to sex as a biological variable (SABV). The review outlines approaches that explore the pertinent role of sex chromosomes and gonadal steroids for delineating sex as a biological independent variable. Next, underlying biological factors that need exploration for blast effects in light of SABV are outlined, including pituitary, autonomic, vascular, and inflammation factors that all have evidence as having important SABV relevance. A major second consideration for the study of SABV and preclinical blast effects is the notable lack of consistent model design-a wide range of devices have been employed with questionable relevance to real-life scenarios-as well as poor standardization for reporting of blast parameters. Hence, the review also provides current views regarding optimal design of shock tubes for approaching the problem of primary blast effects and sex differences and outlines a plan for the regularization of reporting. Standardization and clear description of blast parameters will provide greater comparability across models, as well as unify consensus for important sex difference bioeffects.

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Section: Preclinical Modeling Of Blast For the Study Of Sex Differencmentioning

confidence: 99%

Sex as a Biological Variable in Preclinical Modeling of Blast-Related Traumatic Brain Injury

McCabe

Tucker

2020

Front. Neurol.

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“…Medical and technological advancements in field treatment and care have increased the potential for individuals to be stabilized and to survive conditions that were previously questionable (Pearce & Clasper, 2019). This demonstrates the importance of recognizing the historical context of the data analyzed in this study and the changing landscape that has evolved since 2011 with trauma medical care, especially PT care within the VHA.…”

mentioning

confidence: 99%

Combat veterans with polytrauma and traumatic brain injury: Exploring variables affecting access to social work outpatient services.

et al. 2020

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Polytrauma, or injuries sustained across multiple body locations or systems, has been acknowledged by the Department of Veterans Affairs as an issue of significance for combat veterans of the conflicts commonly referred to as the "war on terror" due to the large number of service members surviving the combat arena who have sustained such injuries. Polytrauma, in the majority of cases, is comorbid with traumatic brain wounds sustained from blast injuries. However, little research guides this area of practice following acute care, especially in relation to social work services, though social workers are the most common outpatient service providers to veterans with this diagnostic sequelae. This exploratory study examines variables associated with access to health care within a large southern Department of Veterans Affairs hospital that is 1 of 5 in the Polytrauma System of Care, a recent addition to veteran's services. Implications and further areas of needed inquiry are discussed.

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Dispatches from the editor: blast injury is everyone’s problem

Garner

Breeze

2018

J R Army Med Corps

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Improving survivability from blast injury: ‘shifting the goalposts’ and the need for interdisciplinary research

Cited by 3 publications

References 18 publications

Sex as a Biological Variable in Preclinical Modeling of Blast-Related Traumatic Brain Injury

Sex as a Biological Variable in Preclinical Modeling of Blast-Related Traumatic Brain Injury

Combat veterans with polytrauma and traumatic brain injury: Exploring variables affecting access to social work outpatient services.

Dispatches from the editor: blast injury is everyone’s problem

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