This chapter examines use of System-Wide Assessments (SWAs) in the Higher Colleges of Technology of the United Arab Emirates. These end-of-course assessments were designed to ensure consistency of standards, to measure student learning outcomes, and to improve the quality and effectiveness of instruction, courses, and programs. The author reviews literature highlighting the importance of outcome assessments, the relevant issues and trends in higher education, the challenges with implementation, and the type of support necessary for enhancing best practices. The chapter primarily describes the design and use of SWAs among the 17 Federal Colleges. It summarizes 2013 survey findings from 232 randomly selected respondents about the level of satisfaction and agreement among faculty and academic chairs about the purpose, process, value, and impact of SWAs. Findings identify what is perceived to be working well including the challenges and issues to promote continuous improvement in SWAs. From experiences and research findings, recommendations are offered for applying best practices and enhancing the effectiveness of assessments in higher education.