Improving Robustness of Pharmaceutical Dosage form Sample Preparation Using Experimental Design and Process Understanding Tools

Ferguson, Paul; Shaw, Robert; McCudden, Adam; Elliot, Claire; Welham, Maire; McAlpine, Vivien; Castel, Clementine; Armstrong, Thomas J.; Yang, Qi; Qiu, Wenlong

doi:10.1007/s10337-020-03969-x

Cited by 4 publications

(1 citation statement)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regarding the emulsion phase ratios, a correlation between an increase in droplet size with an increase in the dispersed phase volume was already reported [ 43 ]. This phenomenon can be correlated with a lack of emulsion stability causing coalescence due to an insufficient concentration of emulsifier to cover the O droplets [ 36 , 44 , 45 ]. An increase in the O phase volume is also associated with a higher emulsion viscosity.…”

Section: Resultsmentioning

confidence: 99%

Design of Experiment for Optimizing Microencapsulation by the Solvent Evaporation Technique

Loureiro,

Aguiar,

Santos

et al. 2023

Polymers

View full text Add to dashboard Cite

We employed microemulsion combined with the solvent evaporation technique to produce biodegradable polycaprolactone (PCL) MCs, containing encapsulated isophorone diisocyanate (IPDI), to act as crosslinkers in high-performance adhesive formulations. The MC production process was optimized by applying a design of experiment (DoE) statistical approach, aimed at decreasing the MCs’ average size. For that, three different factors were considered, namely the concentration of two emulsifiers, polyvinyl alcohol (PVA) and gum arabic (GA); and the oil-to-water phase ratio of the emulsion. The significance of each factor was evaluated, and a predictive model was developed. We were able to decrease the average MC size from 326 μm to 70 µm, maintaining a high encapsulation yield of approximately 60% of the MCs’ weight, and a very satisfactory shelf life. The MCs’ average size optimization enabled us to obtain an improved distributive and dispersive mixture of isocyanate-loaded MCs at the adhesive bond. The MCs’ suitability as crosslinkers for footwear adhesives was assessed following industry standards. Peel tests revealed peel strength values above the minimum required for casual footwear, while the creep test results indicated an effective crosslinking of the adhesive. These results confirm the ability of the MCs to release IPDI during the adhesion process and act as crosslinkers for new adhesive formulations.

show abstract

Section: Resultsmentioning

confidence: 99%