Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1
Callum Beach,
David MacLean,
Dominika Majorova
et al.
Abstract:An immunosuppressive microenvironment causes poor tumor T cell infiltration and is associated with reduced patient overall survival in colorectal cancer. How to improve treatment responses in these tumors is still a challenge. Using an integrated screening approach to identify cancer-specific vulnerabilities, we identified complement receptor C5aR1 as a druggable target, which when inhibited improved radiotherapy, even in tumors displaying immunosuppressive features and poor CD8
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