Improving Quantification of tabun, sarin, soman, cyclosarin, and sulfur mustard by focusing agents: A field portable gas chromatography-mass spectrometry study

Kelly, John T.; Qualley, Anthony; Hughes, Geoffrey T.; Rubenstein, Mitchell H.; Malloy, Thomas A.; Piatkowski, Tedeusz

doi:10.1016/j.chroma.2020.461784

Cited by 16 publications

(15 citation statements)

References 27 publications

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“…thermal desorption-gas chromatography-mass spectrometry) sustav odnosno termalne desorpcijske cjevčice (poput Tenax ® TA) te se razvijaju uređaji koji imaju hvatalo otapala integrirano u sustavu termalne desorpcije. 30,31 Razvoj prijenosnih GC-MS uređaja ide u smjeru postizanja što boljih mogućnosti analize kemijskih spojeva u širokom rasponu masa (uobičajeno od 15 do 550 AMU), što duljeg rada baterije, mogućnosti zamjene baterije i spremnika s helijem bez gašenja instrumenta, što manje veličinu uređaja, učinkovitog rada u što širem vanjskom temperaturnom rasponu, mogućnosti što većeg temperaturnog raspona u plinsko kromatografskom dijelu, lakoće rukovanja te što jednostavnijeg računalnog sučelja. 25 Jedna od mogućnosti uporaba je niskog vakuuma na masenom analizatoru koji omogućuje jednostavniji dizajn, daljnju minijaturizaciju, smanjenje mase uređaja i potrebe za velikom potrošnjom energije, no kod takvog dizajna potrebno je još riješiti problem niske rezolucije na analizatoru masa.…”

Section: Prijenosna Gc-ms Detekcijaunclassified

Tehnologije koje se primjenjuju za terensku detekciju bojnih otrova: II. dio – Detektori nove generacije

Cetina¹,

Tušek²,

Ključarić³

2022

Kemija U Industriji

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Shortly after introduction of commercial automatic chemical detectors, mostly based on ion mobility spectrometry technology, at the end of 20 th century field devices using other chemical detection techniques (FTIR, Raman, GC-MS, surface acoustic wave, photoacoustic, electrochemical, biosensor and others) were developed. Among these techniques, portable GC-MS detectors provide very reliable qualitative and quantitative chemical analysis, but high cost of these devices, the complexity of operating with them and the complexity of sample preparation for analysis present a problem. Some chemical detection technologies cannot be used for the development of a reliable hand-held chemical detector, and not a single technique, for the time being, allows the development of a universal chemical detector. A potential solution is the development of a multi-sensor device that compensates negative sides of each of the sensors. This paper provides an overview of commercially available chemical detectors based on new generation detection technologies and an overview of scientific research focused on further development of detection with simpler, more reliable and preferably cheaper solutions is given.

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Section: Prijenosna Gc-ms Detekcijaunclassified

Tehnologije koje se primjenjuju za terensku detekciju bojnih otrova: II. dio – Detektori nove generacije

Cetina¹,

Tušek²,

Ključarić³

2022

Kemija U Industriji

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“…The need exists to detect and quantitate chemical warfare agents (CWAs) in the field in order to protect those who may be at risk of exposure. The portable GCMS systems are most advantageous since deployment in the field yields shorter data turnaround times as samples do not have to be transported to laboratories for analysis [17,18]. Besides short turnaround time, reproducible CWA absolute quantitation data for portable GCMS is very important due to the high toxicity of these substances.…”

Section: Case Study 3: Introductionmentioning

confidence: 99%

“…Besides short turnaround time, reproducible CWA absolute quantitation data for portable GCMS is very important due to the high toxicity of these substances. Shown in Figure 4, the analytes of interest in this study were the G-series nerve agents tabun, sarin, soman, and cyclosarin and the blistering agent sulfur mustard [18]. Previous work showed the possibility of using response factors (analyte peak area/internal standard peak area) for quantitating G-series nerve agents using Hapsite and Hapsite ER portable GCMS systems [19].…”

Section: Case Study 3: Introductionmentioning

confidence: 99%

Uses of Portable Gas Chromatography Mass Spectrometers

Bussey¹

2023

Novel Aspects of Gas Chromatography and Chemometrics

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Gas chromatography mass spectrometry (GCMS) technology, whether in a laboratory or in the field allows scientists to identify and quantitate volatile and semi-volatile chemical compounds at low levels. It was not until the 1990s, well after the birth of GCMS in the 1950’s, that portable GCMS technology became possible. GCMS miniaturization along with a need for scientists to test samples outside of the laboratory drove the development of portable GCMS systems. Currently, scientists in the environmental, emergency response, government, military sectors, and private manufacturing industries use portable GCMS technology to monitor and quantitate various chemicals such as low levels of hazardous compound exposure in the environment. Successful implementation of portable GCMS also required that many sample preparatory techniques used in the laboratory must be modified for application in the field to maintain simplicity and robustness of the analysis of complex matrices like soil or water. This chapter will describe portable GCMS technology along with the current uses and sample preparatory techniques utilized.

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“…Portable GC-MS enables the detection and identification of CWA with high accuracy [ 15 ]. However, these devices are still expensive and require well-trained staff.…”

Section: Introductionmentioning

confidence: 99%

Acoustic Wave Sensors for Detection of Blister Chemical Warfare Agents and Their Simulants

Grabka

Witkiewicz

Jasek

et al. 2022

Sensors

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On-site detection and initial identification of chemical warfare agents (CWAs) remain difficult despite the many available devices designed for this type of analysis. Devices using well-established analytical techniques such as ion mobility spectrometry, gas chromatography coupled with mass spectrometry, or flame photometry, in addition to unquestionable advantages, also have some limitations (complexity, high unit cost, lack of selectivity). One of the emerging techniques of CWA detection is based on acoustic wave sensors, among which surface acoustic wave (SAW) devices and quartz crystal microbalances (QCM) are of particular importance. These devices allow for the construction of undemanding and affordable gas sensors whose selectivity, sensitivity, and other metrological parameters can be tailored by application of particular coating material. This review article presents the current state of knowledge and achievements in the field of SAW and QCM-based gas sensors used for the detection of blister agents as well as simulants of these substances. The scope of the review covers the detection of blister agents and their simulants only, as in the available literature no similar paper was found, in contrast to the detection of nerve agents. The article includes description of the principles of operation of acoustic wave sensors, a critical review of individual studies and solutions, and discusses development prospects of this analytical technique in the field of blister agent detection.

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Improving Quantification of tabun, sarin, soman, cyclosarin, and sulfur mustard by focusing agents: A field portable gas chromatography-mass spectrometry study

Cited by 16 publications

References 27 publications

Tehnologije koje se primjenjuju za terensku detekciju bojnih otrova: II. dio – Detektori nove generacije

Tehnologije koje se primjenjuju za terensku detekciju bojnih otrova: II. dio – Detektori nove generacije

Uses of Portable Gas Chromatography Mass Spectrometers

Acoustic Wave Sensors for Detection of Blister Chemical Warfare Agents and Their Simulants

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