Improving quality management of newborn screening in southwest China

Yu, Chao-wen; He, Xiaoyan; Wan, Ke-Xing; Yuan, Zhaojian; Líu, Hao; Zhang, Juan; Liu, Shan; Yang, Jing; Zou, Lin

doi:10.1177/03000605211002999

Cited by 7 publications

(4 citation statements)

References 20 publications

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“…Our findings are in tandem with the results by El-Shal et al, who showed that accreditation in Egypt was associated with significant improvements in child morbidity, family planning, and delivery care [7]. Similarly, Chao-Wen et al, in South West China, reported improvements in in a new born screening program for indicators including new born health education provision, dried blood sampling, turnaround time, new born recall after positive primary screening following implementation of a comprehensive quality management system [32].…”

Section: Maternal and Child Health Servicesmentioning

confidence: 63%

Impact of accreditation on health care services performance in Kiryandongo district, Uganda: a longitudinal study

Matovu¹,

Musiime²,

Olak

et al. 2022

BMC Health Serv Res

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Background The COVID-19 pandemic has emphasised the need for quality laboratory services worldwide. There is renewed focus to strengthen country capacities and laboratories to effectively respond to public health emergencies and patient outcomes. Uganda launched the accreditation program for public health facilities in 2016 with sixteen laboratories. As of June 2021, twenty-three public laboratories have attained ISO 15189:2012 accreditation status. Despite the tremendous achievements of accrediting laboratories in Uganda, laboratory services still face challenges like stock out of commodities and limited testing scopes. We conducted this study to evaluate the impact of accreditation on health care services performance in Kiryandongo district, Uganda. Methods We conducted a longitudinal study from January 1, 2020- April 30, 2021 at ten health facilities in Kiryandongo district. We collected health care services performance data from the MoH dhis-2 on selected indicators for HIV, TB, Malaria, Laboratory, Maternal & child health and dhis-2 reporting. We used Generalized Estimating Equations to estimate the impact of accreditation on health care services performance at the different health facilities. Results The odds at the accredited facility in comparison to the non-accredited public facilities were; 14% higher for ART enrolment (OR = 1.14, 95% CI: 1.04–1.25), 9% lower for determine testing kits stock out (OR = 0.91, 95% CI: 0.85–0.97), 28% higher for TB case diagnosis (OR = 1.28, 95% CI: 1.10–1.49), 19% higher for TB case enrolment (OR = 1.19, 95% CI: 1.04–1.36), 104% higher for maternity admissions (OR = 2.04, 95% CI: 1.60–2.59), 63% higher for maternity deliveries (OR = 1.63, 95% CI: 1.39–1.90) and 17% higher for reporting hmis 10:01 data to dhis-2 (OR = 1.17, 95% CI: 1.04–1.31). The odds at the accredited facility in comparison to the non-accredited PNFP facilities were; 26% higher for ART enrolment (OR = 1.26, 95% CI: 1.17–1.36), 33% higher for TB case diagnosis (OR = 1.33, 95% CI: 1.15–1.55), 24% higher for TB case enrolment (OR = 1.24, 95% CI: 1.09–1.42), 136% higher for maternity admissions (OR = 2.36, 95% CI: 1.89–2.94), 76% higher for maternity deliveries (OR = 1.76, 95% CI: 1.51–2.04) and 2% higher for reporting of hmis-10:01 data to dhis-2 (OR = 1.02, 95% CI: 1.01–1.03). Conclusions HIV, TB, laboratory, MCH, and reporting to dhis-2 selected indicators were positively impacted by accreditation. This impact translated into increased health care services performance at the accredited facility as compared to the non-accredited facilities.

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Section: Maternal and Child Health Servicesmentioning

confidence: 63%

Impact of accreditation on health care services performance in Kiryandongo district, Uganda: a longitudinal study

Matovu¹,

Musiime²,

Olak

et al. 2022

BMC Health Serv Res

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“…There are several recent reports related to expanded NBS with MS/MS: an evaluation of MS/MS implementation in Suqian city (North) [ 447 ]; analyses of the cost effectiveness of ENBS in Shenzhen (South) [ 448 ] and Zhejiang province (East) [ 449 ]; and studies to determine the disease spectrum and genetic characteristics of IEMs detected by ENBS in Xi’an city (Northwest) [ 450 ] and Changsha (Central) [ 451 ]. A robust system-wide quality management system exists including both laboratories (National Center for Clinical Laboratories) [ 452 ] and non-laboratory components [ 453 ], sometimes augmented by regional quality improvement activities [ 454 ]. A large study was reported in 2021 that determined normal ranges for 35 MS/MS conditions in the Chinese newborn population [ 455 ].…”

Section: Resultsmentioning

confidence: 99%

Current Status of Newborn Bloodspot Screening Worldwide 2024: A Comprehensive Review of Recent Activities (2020–2023)

Therrell,

Padilla,

Borrajo

et al. 2024

IJNS

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Newborn bloodspot screening (NBS) began in the early 1960s based on the work of Dr. Robert “Bob” Guthrie in Buffalo, NY, USA. His development of a screening test for phenylketonuria on blood absorbed onto a special filter paper and transported to a remote testing laboratory began it all. Expansion of NBS to large numbers of asymptomatic congenital conditions flourishes in many settings while it has not yet been realized in others. The need for NBS as an efficient and effective public health prevention strategy that contributes to lowered morbidity and mortality wherever it is sustained is well known in the medical field but not necessarily by political policy makers. Acknowledging the value of national NBS reports published in 2007, the authors collaborated to create a worldwide NBS update in 2015. In a continuing attempt to review the progress of NBS globally, and to move towards a more harmonized and equitable screening system, we have updated our 2015 report with information available at the beginning of 2024. Reports on sub-Saharan Africa and the Caribbean, missing in 2015, have been included. Tables popular in the previous report have been updated with an eye towards harmonized comparisons. To emphasize areas needing attention globally, we have used regional tables containing similar listings of conditions screened, numbers of screening laboratories, and time at which specimen collection is recommended. Discussions are limited to bloodspot screening.

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“…Besides, several MS instruments developed by different manufacturers have been approved for the screening of neonatal inherited metabolic disorders. Although all kits' manufacturers performed meteorological tracing according to ISO17511 as reported, 13 there are differences among the clinical reference ranges of each analyte according to the manuals in those kits, 14 which indicate that there is still a need for national evaluation across laboratories in China based on certified reference materials.…”

Section: Introductionmentioning

confidence: 99%

Harmonization of distributed multi‐center analysis based on dried blood spot reference materials supporting the screening of neonatal inherited metabolic disorders

Qu,

Tao,

Qin

et al. 2023

Clinical Laboratory Analysis

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BackgroundThe standardization of quantification data is critical for ensuring the reliability and measurement traceability in the screening of neonatal inherited metabolic disorders. However, the availability of national certified reference materials is limited in China.MethodsIn this study, we developed a series of dried blood spot (DBS) reference materials containing 9 amino acids (AA) and 10 acylcarnitines (AC) for neonatal screening. Four levels of the reference materials were measured with tandem mass spectrometry (MS/MS) by seven laboratories using different commercial In Vitro Diagnostic Device (IVD) kits. Then, 100 clinical samples were measured using both derivatization and non‐derivatization methods by the same laboratory.ResultsWe found high homogeneity and stability at all levels of the reference materials, with the coefficient of variation (CV) of the analytes less than 15%. These reference materials can be used to assess the testing capabilities of different laboratories. Our test also revealed that the correction factors (CF) calculated by the reference materials, along with clinical samples, could increase the consistency for different kits.ConclusionThe DBS reference materials proposed in this study provide reliability for the harmonization in multi‐center analysis for the screening of neonatal inherited metabolic disorders. And applying our correction method for the screening could improve the data consistency of the DBS samples prepared by different methods.

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Improving quality management of newborn screening in southwest China

Cited by 7 publications

References 20 publications

Impact of accreditation on health care services performance in Kiryandongo district, Uganda: a longitudinal study

Impact of accreditation on health care services performance in Kiryandongo district, Uganda: a longitudinal study

Current Status of Newborn Bloodspot Screening Worldwide 2024: A Comprehensive Review of Recent Activities (2020–2023)

Harmonization of distributed multi‐center analysis based on dried blood spot reference materials supporting the screening of neonatal inherited metabolic disorders

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