This article describes the design and verification of the indirect method of predicting the course of CO 2 concentration (ppm) from the measured temperature variables T indoor (°C) and the relative humidity rH indoor (%) and the temperature T outdoor (°C) using the Artificial Neural Network (ANN) with the Bayesian Regulation Method (BRM) for monitoring the presence of people in the individual premises in the Intelligent Administrative Building (IAB) using the PI System SW Tool (PI-Plant Information enterprise information system). The CA (Correlation Analysis), the MSE (Root Mean Squared Error) and the DTW (Dynamic Time Warping) criteria were used to verify and classify the results obtained. Within the proposed method, the LMS adaptive filter algorithm was used to remove the noise of the resulting predicted course. In order to verify the method, two long-term experiments were performed, specifically from February 1 to