Improving ovarian cancer imaging with LHRH-NBs: an experimental study

Li, Wenjuan; Zhang, Lingping; Zhu, Yue; Zhang, Jinyi; Shen, Li; Huang, Shuying; Fang, Shanyu

doi:10.1007/s00404-016-4092-z

Cited by 3 publications

(2 citation statements)

References 19 publications

(21 reference statements)

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“…Nanobubbles have shown improved permeation into tissue and longer tissue retention times relative to microbubbles in non-ovarian tumor studies [ 118 ]. They have also demonstrated good signal accumulation and retention in ovarian tumor bearing mice, however, in recent nanobubbles studies as both untargeted contrast agents and as molecular imaging agents [ 119 , 120 , 121 ]. Critically, however, these studies are limited to xenograft subcutaneous ovarian tumors, and the technology has yet to be implemented in orthotopic or syngeneic models.…”

Section: Recent Developments Of Nanoparticles For Ovarian Cancer Diagnosticsmentioning

confidence: 99%

The Development of Nanoparticles for the Detection and Imaging of Ovarian Cancers

et al. 2021

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Ovarian cancer remains as one of the most lethal gynecological cancers to date, with major challenges associated with screening, diagnosis and treatment of the disease and an urgent need for new technologies that can meet these challenges. Nanomaterials provide new opportunities in diagnosis and therapeutic management of many different types of cancers. In this review, we highlight recent promising developments of nanoparticles designed specifically for the detection or imaging of ovarian cancer that have reached the preclinical stage of development. This includes contrast agents, molecular imaging agents and intraoperative aids that have been designed for integration into standard imaging procedures. While numerous nanoparticle systems have been developed for ovarian cancer detection and imaging, specific design criteria governing nanomaterial targeting, biodistribution and clearance from the peritoneal cavity remain key challenges that need to be overcome before these promising tools can accomplish significant breakthroughs into the clinical setting.

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Section: Recent Developments Of Nanoparticles For Ovarian Cancer Diagnosticsmentioning

confidence: 99%

The Development of Nanoparticles for the Detection and Imaging of Ovarian Cancers

et al. 2021

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“…Therefore, the application of micro/ nano-scale bubbles is very extensive. [10][11][12] The initial microbubbles have no membrane coating, so the action time in vivo is very short. The current microbubbles are vesicles coated with a shell membrane.…”

Section: Introductionmentioning

confidence: 99%

Construction of novel amphiphilic chitosan-polylactide graft copolymer nanodroplets for contrast enhanced ultrasound tumor imaging

Wang

Ding

et al. 2021

J Biomater Appl

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In this experiment, a new amphiphilic chitosan-poly(lactide) graft copolymer was synthesized and characterized by IR, 1H-NMR, XRD, TGA. The obtained chitosan-poly (lactide) graft copolymer was used as the matrix material to prepare nanodroplets (NDs) encapsulating with liquid PFP by double-emulsion and solvent evaporation method. The resulting NDs were characterized by photon correlation spectroscopy and transmission electron microscopy (TEM). The biocompatibility was explored by cytotoxicity assay, cell migration assay and blood biochemistry analysis. The experiments of ultrasonic imaging in vitro and in vivo were carried out with a B-mode clinical ultrasound imaging system. The results of FI-IR and 1H-NMR confirmed the successful grafting reaction of polylactic acid(PLLA) to chitosan with a graft rate of 365%. The average size of the NDs was 101.1 ± 2.7 nm, with the polydispersity index (PDI) of 0.127 ± 0.020, and the zeta potential was −31.8 ± 1.5 mV. From the TEM results, NDs were highly dispersed and had a spherical shape with a distinct capsule structure. The NDs exhibited good stability during storage at 4°C. The NDs solution with different concentrations did not affect cell growth and showed good biocompatibility in cytotoxicity, cell migration and blood biochemistry studies. Under the irradiation of ultrasonic waves, the NDs formed an ultrasonic high signal, which could significantly enhance the ultrasound imaging of tumor tissue in vivo. Taken together, the NDs hold great potential for ultrasound imaging as a nanosized contrast agent.

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3D-printed smartphone-based point of care tool for fluorescence- and magnetophoresis-based cytometry

et al. 2017

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In developing countries, there are often limited resources available to provide important medical diagnostics, which severely limits our ability to diagnose conditions and administer proper treatment, leading to high mortality rates for treatable conditions. Here, we propose a multiplex tool capable of density-based cell sorting via magnetic focusing in parallel with fluorescence imaging to provide highly specific clinical assays. While many cell sorting techniques and fluorescence microscopes generally are costly and require extensive user training, limiting accessibility and usability in developing countries, this device is compact, low-cost, and portable. The device can separate cells on the basis of density, which can be used to identify cell type and cell activity, and image the cells in either brightfield, darkfield, or fluorescent imaging modes using the built-in smartphone camera. The combination of these two powerful and versatile techniques - magnetic focusing and fluorescence imaging - will make this platform broadly applicable to a range of biomedical assays. Clinical applications include cell cytometry and immunocytochemistry-based assays in limited-resource settings, which can ultimately help to improve worldwide accessibility to medical diagnostics.

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Improving ovarian cancer imaging with LHRH-NBs: an experimental study

Cited by 3 publications

References 19 publications

The Development of Nanoparticles for the Detection and Imaging of Ovarian Cancers

The Development of Nanoparticles for the Detection and Imaging of Ovarian Cancers

Construction of novel amphiphilic chitosan-polylactide graft copolymer nanodroplets for contrast enhanced ultrasound tumor imaging

3D-printed smartphone-based point of care tool for fluorescence- and magnetophoresis-based cytometry

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