Improving Outcomes in Severe Sepsis and Septic Shock: Results of a Prospective Multicenter Collaborative

Cannon, Chad; Holthaus, Christopher V.; Rivers, Emanuel P.; Gunaga, Satheesh; Zubrow, Marc T.; Posa, Pat; Elkins, Ronald C.; Turman, Bonnie; Kella, V.; Davis, Scott; Lidsky, Nathan; Milling, Truman J.

doi:10.1016/j.jemermed.2009.06.022

Cited by 5 publications

(2 citation statements)

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“…8 Whether EGDT was performed in the ED or the ICU, these studies have shown that the outcome benefit equals or exceeds the original EGDT study. 32,51,53 This shows that EGDT can be performed in the community hospital setting. From a quality perspective, awards provided by the Joint Commission for Hospital Accreditation Organization (The Codman Award) have gone to programs implementing EGDT in the past 2 years.…”

Section: The Outcome Evidencementioning

confidence: 82%

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Implementing Sepsis Quality Initiatives in a Multiprofessional Care Model

Rivers¹,

Rubinfeld²,

Manteuffel³

et al. 2011

ICU Director

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Studies of acute myocardial infarction, trauma, and stroke have resulted in improved outcomes through earlier diagnosis and application of therapy at the most proximal stage of hospital presentation. Most critical therapies for these diseases are frequently instituted prior to admission to an ICU. This systems-based approach to the sepsis patient has been lacking. To change this paradigm, a trial comparing early goal-directed therapy (EGDT) versus standard care was performed using specifi c criteria for the early identifi cation of high-risk sepsis patients and a consensus-derived protocol to reverse the hemodynamic perturbations of hypovolemia, vasoregulation, myocardial suppression, and increased metabolic demands. One decade later, EGDT has been shown to modulate infl ammation, decrease the progression of organ failure, improve microcirculatory function, and decrease health resource consumption and mortality. A standard operating procedure beginning with EGDT for severe sepsis and septic shock is a hospital-wide initiative.

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Section: The Outcome Evidencementioning

confidence: 82%

“…[54][55][56] The mean hospital length of stay was 5.02 days shorter and hospital charges were $47 923 less between groups (both statistically significant, P < .0001). 53 Even when factoring in additional overhead costs; a sepsis quality initiative is cost-effective.…”

Section: The Socioeconomic Benefit Of a Sepsis Quality Initiativementioning

confidence: 99%