Improving our understanding of metal implant failures: Multiscale chemical imaging of exogenous metals in ex-vivo biological tissues

Morrell, Alexander P.; Floyd, H. Landis; Mosselmans, J. F. W.; Grover, Liam M.; Castillo‐Michel, Hiram; Davis, Edward T.; Parker, Julia; Martin, Richard A.; Addison, Owen

doi:10.1016/j.actbio.2019.05.071

Cited by 21 publications

(22 citation statements)

References 51 publications

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“…Criteria for ROI definition were focal metal exposure as well as the presence of biological alterations like osteolysis of cancellous bone, fibrous and inflammatory or necrotic changes within the marrow structures. Scans were performed over these ROIs at medium resolution (10,3, and 2 µm) and quantitative mass fraction maps were calculated in whole scans or in specific areas of these maps ( Figure 1D). Samples were then transferred to the nanoprobe ID16B.…”

Section: Study Design and Experimental Strategymentioning

confidence: 99%

“…[ 9 ] Recently, it was shown that metal species are highly diverse in the peri‐implant membrane of metal‐on‐metal (MOM) hip implants. [ 10 ] The diversity of metal speciation will even be more pronounced in the future due to recent advances in nanosized surface modifications of materials used for biomedical applications. [ 11 ] While the ex vivo exposure assessment of metals released from implants with articulating metal surfaces is commonly described in literature, the steady release of metal wear debris from surfaces of load‐bearing but non‐articulating implant components is largely disregarded.…”

Section: Introductionmentioning

confidence: 99%

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Metal‐Specific Biomaterial Accumulation in Human Peri‐Implant Bone and Bone Marrow

et al. 2020

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Metallic implants are frequently used in medicine to support and replace degenerated tissues. Implant loosening due to particle exposure remains a major cause for revision arthroplasty. The exact role of metal debris in sterile peri-implant inflammation is controversial, as it remains unclear whether and how metals chemically alter and potentially accumulate behind an insulating peri-implant membrane, in the adjacent bone and bone marrow (BM). An intensively focused and bright synchrotron X-ray beam allows for spatially resolving the multi-elemental composition of peri-implant tissues from patients undergoing revision surgery. In peri-implant BM, particulate cobalt (Co) is exclusively co-localized with chromium (Cr), non-particulate Cr accumulates in the BM matrix. Particles consisting of Co and Cr contain less Co than bulk alloy, which indicates a pronounced dissolution capacity. Particulate titanium (Ti) is abundant in the BM and analyzed Ti nanoparticles predominantly consist of titanium dioxide in the anatase crystal phase. Co and Cr but not Ti integrate into peri-implant bone trabeculae. The characteristic of Cr to accumulate in the intertrabecular matrix and trabecular bone is reproducible in a human 3D in vitro model. This study illustrates the importance of updating the view on long-term consequences of biomaterial usage and reveals toxicokinetics within highly sensitive organs.

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Section: Study Design and Experimental Strategymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Metal‐Specific Biomaterial Accumulation in Human Peri‐Implant Bone and Bone Marrow

et al. 2020

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“…Early beamline publications (McCulloch et al, 2019;Gomez-Gonzalez et al, 2019;Morrell et al, 2019;Walker et al, 2018) highlight some of the XRF, nano-XANES and nano-XRD capabilities. Fig.…”

Section: User Operationsmentioning

confidence: 99%

The Hard X-ray Nanoprobe beamline at Diamond Light Source

Quinn¹,

Alianelli²,

Gomez-Gonzalez³

et al. 2021

J Synchrotron Rad

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The Hard X-ray Nanoprobe beamline, I14, at Diamond Light Source is a new facility for nanoscale microscopy. The beamline was designed with an emphasis on multi-modal analysis, providing elemental mapping, speciation mapping by XANES, structural phase mapping using nano-XRD and imaging through differential phase contrast and ptychography. The 185 m-long beamline operates over a 5 keV to 23 keV energy range providing a ≤50 nm beam size for routine user experiments and a flexible scanning system allowing fast acquisition. The beamline achieves robust and stable operation by imaging the source in the vertical direction and implementing horizontally deflecting primary optics and an overfilled secondary source in the horizontal direction. This paper describes the design considerations, optical layout, aspects of the hardware engineering and scanning system in operation as well as some examples illustrating the beamline performance.

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“…30 %. As with cobalt, chromium is released locally from joint prosthesis components and is present in the peri-implant compartments as trivalent chromium oxide or chromium phosphate [30,31]. Determining the chemical specification of wear and corrosion products is important, given that trivalent chromium is rated as far less toxic in comparison with hexavalent chromium [32].…”

Section: Chromiummentioning

confidence: 99%

“…The quotient between systemic and local metal concentrations is smaller for chromium than for cobalt. This difference in the biokinetics may be explained by the high tissue-binding affinity of chromium as well as a greater solubility and greater release of cobalt secondary to corrosion [1,30,34,35]. Higher renal elimination of cobalt compared to chromium, however, results in comparatively longer persistence of elevated chromium levels after termination of exposure by revision surgery [36 -39].…”

Section: Chromiummentioning

confidence: 99%

Systemic Effects of Metals Released from Arthroplasty Implants – a Brief Summary

Rakow

Schoon

2020

Z Orthop Unfall

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In recent years, increasing concern has been raised regarding potential systemic toxicity of metals released from arthroplasty implants. A lack of valid metal thresholds for human (organ) toxicity and the prospect of multi-decade survival of modern hip and knee replacements pose special challenges. Indeed, evidence of systemic effects of metals released from such implants is largely missing. Systemic cobalt exposure has repeatedly been associated with cardiotoxic and neurotoxic effects, and also with thyroid dysfunction. The toxic potential of chromium is considered less pronounced. Yet, in arthroplasty there is usually a co-exposure to chromium and cobalt which complicates evaluation of element-specific effects. Toxicity of titanium dioxide nanoparticles has been subject to debate among international regulatory authorities. Their wide use in a variety of products in everyday life, such as toothpaste, cosmetics and food colorants, hampers the assessment of an arthroplasty-induced systemic titanium exposure. To date there is no clear evidence for systemic complications due to titanium dioxide released from arthroplasty implants. Release of further metals such as tantalum, niobium, nickel, vanadium and zirconium from hip and knee replacement implants has been described occasionally, but systemic effects of respective long-term exposure scenarios are unknown. Generally, the characterization of all released metals regarding their chemical and physical specifications is critical for the evaluation of potential systemic risks. Systematic studies investigating the accumulation of metals relevant in arthroplasty in different organs/organ systems and the biological consequences of such accumulations are urgently needed.

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Improving our understanding of metal implant failures: Multiscale chemical imaging of exogenous metals in ex-vivo biological tissues

Cited by 21 publications

References 51 publications

Metal‐Specific Biomaterial Accumulation in Human Peri‐Implant Bone and Bone Marrow

Metal‐Specific Biomaterial Accumulation in Human Peri‐Implant Bone and Bone Marrow

The Hard X-ray Nanoprobe beamline at Diamond Light Source

Systemic Effects of Metals Released from Arthroplasty Implants – a Brief Summary

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