Improving nitrofurantoin resistance prediction in
Escherichia coli
from whole-genome sequence by integrating NfsA/B enzyme assays
Punyawee Dulyayangkul,
Jordan E. Sealey,
Winnie W. Y. Lee
et al.
Abstract:Nitrofurantoin resistance in
Escherichia coli
is primarily caused by mutations damaging two enzymes, NfsA and NfsB. Studies based on small isolate collections with defined nitrofurantoin MICs have found significant random genetic drift in
nfsA
and
nfsB
, making it extremely difficult to predict nitrofurantoin resistance from whole-genome sequence (WGS) where both genes are not obviously disrupted by nonsense or frameshift mutat… Show more
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