Improving mouse models for the study of Alzheimer's disease

Reagan, Alaina M.; Onos, Kristen D.; Heuer, Sarah; Sasner, Michael; Howell, Gareth R.

doi:10.1016/bs.ctdb.2021.12.005

Cited by 2 publications

(2 citation statements)

References 146 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…She provided examples of each of these types of studies and pointed out the pros and cons of each approach dependent upon the specific research question being addressed. She introduced what are known as wild‐derived mouse strains which comprise the founders of the CC and DO mouse populations, and how AD researchers are incorporating these lines into their research to model genetic and phenotypic diversity 39,40 . Dr. Onos highlighted the utility of the wild‐derived mouse strains for immune system functioning given that they were caught more recently in the wild from different regions across the world and while they are maintained as inbred, the critical processes of immune system functioning remain relatively conserved 39,41 .…”

Section: Introductionmentioning

confidence: 99%

“…She introduced what are known as wild‐derived mouse strains which comprise the founders of the CC and DO mouse populations, and how AD researchers are incorporating these lines into their research to model genetic and phenotypic diversity. 39 , 40 Dr. Onos highlighted the utility of the wild‐derived mouse strains for immune system functioning given that they were caught more recently in the wild from different regions across the world and while they are maintained as inbred, the critical processes of immune system functioning remain relatively conserved. 39 , 41 Course participants were enthusiastic about learning these approaches, and previous participants have gone on to use these strains in their research.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Meeting report of the fifth annual workshop on Principles and Techniques for Improving Preclinical to Clinical Translation in Alzheimer's Disease Research

Sasner,

Onos,

Territo

et al. 2024

Alzheimer's & Dementia

Self Cite

View full text Add to dashboard Cite

The fifth annual workshop on Principles and Techniques for Improving Preclinical Translation of Alzheimer's Disease Research was held in May 2023 at The Jackson Laboratory in Bar Harbor, Maine, USA. The workshop was established in 2018 to address training gaps in preclinical translational studies for Alzheimer's disease (AD). In addition to providing fundamental knowledge and hands‐on skills essential for executing rigorous in vivo studies that are designed to facilitate translation, each year the workshop aims to provide insight on state‐of‐the‐field technological advances and new resources including novel animal models, publicly available datasets, novel biomarkers, and new medical imaging tracers. This innovative and comprehensive workshop continues to deliver training for the greater AD research community in order to provide investigators and trainees with the knowledge and skillsets essential for enabling improved preclinical to clinical translation and accelerate the process of advancing safe and effective therapeutic interventions for AD.Highlights Translational research is not typically available as a course of study at academic institutions, yet there are fundamental skillsets and knowledge required to enable successful translation from preclinical experiments to clinical efficacy. It is important that there are resources and opportunities available to researchers planning preclinical translational experiments. Here we present proceedings from the fifth annual NIA‐sponsored workshop focused on enabling improved preclinical to clinical translation for Alzheimer's disease research that includes didactic lectures on state‐of‐the‐field approaches and hands‐on practicums for acquiring essential translational laboratory techniques.

show abstract

Section: Introductionmentioning

confidence: 99%