Improving Microbial Cell Factory Performance by Engineering SAM Availability
Yongkun Lv,
Jinmian Chang,
Weiping Zhang
et al.
Abstract:Methylated natural products are widely spread in nature. S-Adenosyl-L-methionine (SAM) is the secondary abundant cofactor and the primary methyl donor, which confer natural products with structural and functional diversification. The increasing demand for SAM-dependent natural products (SdNPs) has motivated the development of microbial cell factories (MCFs) for sustainable and efficient SdNP production. Insufficient and unsustainable SAM availability hinders the improvement of SdNP MCF performance. From the pe… Show more
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