Improving mechanical properties of desloratadine via multicomponent crystal formation

Improved Solubility and Dissolution Rates in Novel Multicomponent Crystals of Piperine with Succinic Acid

“…In general, a multicomponent crystal phase includes a salt, cocrystal, hydrate, and solvate [32,33]. Numerous studies have demonstrated that the formation of a multicomponent crystal phase of API with a suitable excipient could enhance its physicochemical properties, such as solubility and dissolution rate, permeability, bioavailability, physical stability, compressibility, and pharmacological efficacy [34][35][36][37][38][39]. To the best of our knowledge, only two studies on the multicomponent crystal phase of piperine have been reported: a cocrystal with resveratrol, and a salt with a halide [40,41].…”

Crystal Structural Analysis of DL-Mandelate Salt of Carvedilol and Its Correlation with Physicochemical Properties

“…However, no report has investigated the X-ray singlecrystal structure of either of the polymorphic forms of this salt. Our ongoing research is focused on improving the physicochemical properties of pharmaceutical drug molecules by inducing multicomponent crystals, such as cocrystals, salt, and its solvates [44][45][46][47][48]. Moreover, we aim to establish new crystalline solid forms of the API.…”

Mechanical properties of coordination polymer-based dietary supplements

“…Fortunately, crystal engineering is widely utilized in designing active pharmaceutical ingredients (APIs) to solve above problems, and it can also be used to tune the mechanical properties such as grindability and tabletability. For example, there are many studies for adopting the optimum measures of constructing tablet product, such as cocrystallization [19][20][21], hydrates [22,23], salt formation [24] and multicomponent crystals [25].…”

“…Notably, one of the significant physicochemical properties of APIs is their mechanical properties (e.g., plasticity and elasticity). During tableting process of pharmaceutical powder, the crystals are milled and compacted, and the elastic and plastic properties during this complex process directly influence the powder tabletability [9,21,[25][26][27]. For example, strong elastic recovery (the extent of slight recover during the decompression and ejection phases) after compression is considered as the main reason of adverse phenomena such as capping or delamination of tablets [17,18,25].…”

“…During tableting process of pharmaceutical powder, the crystals are milled and compacted, and the elastic and plastic properties during this complex process directly influence the powder tabletability [9,21,[25][26][27]. For example, strong elastic recovery (the extent of slight recover during the decompression and ejection phases) after compression is considered as the main reason of adverse phenomena such as capping or delamination of tablets [17,18,25]. Furthermore, a better plasticity (the ability for a material undergoing permanent shape change, local structural distortion and irreversible deformation under the stress) via slipping in a crystal may result in more facile milling and better tabletability, which usually originates from the motions of dislocation along some specific slipped planes [25,27].…”