Improving material properties of a poloxamer P407 hydrogel‐based hydroxyapatite bone substitute material by adding silica—A comparative in vivo study
Peer W. Kämmerer,
Diana Heimes,
Franziska Zaage
et al.
Abstract:The structure and handling properties of a P407 hydrogel‐based bone substitute material (BSM) might be affected by different poloxamer P407 and silicon dioxide (SiO2) concentrations. The study aimed to compare the mechanical properties and biological parameters (bone remodeling, BSM degradation) of a hydroxyapatite: silica (HA)‐based BSM with various P407 hydrogels in vitro and in an in vivo rat model. Rheological analyses for mechanical properties were performed on one BSM with an SiO2‐enriched hydrogel (SPH2… Show more
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