Improving imputation quality in Samoans through the integration of population-specific sequences into existing reference panels
Jenna C. Carlson,
Mohanraj Krishnan,
Shuwei Liu
et al.
Abstract:Genotype imputation is fundamental to association studies, and yet even gold standard panels like TOPMed are limited in the populations for which they yield good imputation. Specifically, Pacific Islanders are poorly represented in extant panels. To address this, we constructed an imputation reference panel using 1,285 Samoan individuals with whole-genome sequencing, combined with 1000 Genomes (1000G) samples, to create a reference panel that better represents Pacific Islander, specifically Samoan, genetic var… Show more
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