Improving SUVR quantification by correcting for radiotracer clearance in tissue
Praveen Honhar,
David Matuskey,
Richard E Carson
et al.
Abstract:Standardized Uptake Value Ratio ( SUVR) is a widely reported semi-quantitative positron emission tomography (PET) outcome measure, partly because of its ease of measurement from short scan durations. However, in brain, SUVR is often a biased estimator of the gold-standard distribution volume ratio ( DVR) due to non-equilibrium conditions, i.e., clearance of the radiotracer in relevant tissues. Factors that affect radiotracer metabolism and clearance such as medication or subject groups could lead to artificial… Show more
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