Improving in vivo Uranyl Removal Efficacy of a Nano‐Metal Organic Framework by Interior Functionalization with 3‐Hydroxy‐2‐pyridinone

Abstract

Comprehensive Summary The environmental contamination of uranium will occur in scenarios such as nuclear accidents and leakage from nuclear waste storage sites, which eventually leads to the internal uranium exposure of people, causing consequential injuries of renal failure, osteosarcoma, etc. The development of uranyl specific chelating agents that could sequester uranium in vivo is in urgent need and is important for the safe and efficient development of nuclear industry. Metal organic frameworks (MOFs) already serve as efficient uranium depletion materials in solutions of a wide range of pH and ionic strength for nuclear fuel recycling, uranium extraction from seawater, as well as environmental decontamination. Herein, a chromium‐based nano‐metal organic framework (nano‐MOF) functionalized interiorly with 3,2‐HOPO ligands, MIL‐101‐HOPO, is rationally synthesized. In vitro adsorption experiments show that MIL‐101‐HOPO exhibits high adsorption selectivity and fast adsorption kinetics for uranyl. The results of in vivo uranyl decorporation assays reveal that MIL‐101‐HOPO with the decoration of HOPO ligands on the interior wall exhibits significantly increased uranyl removal ratio in kidneys comparing to the pristine nMOFs, and is more effective than the clinically used ZnNa3‐DTPA. All those results corroborate the interior functionalization of MOFs as an efficient strategy to develop promising uranyl decorporation agents.

A Pyrazine‐Based 2D Conductive Metal‐Organic Framework for Efficient Lithium Storage†

“…With the increased reliance on portable uninterruptible power supplies and the demand of green and sustainable energy, cost‐effective electric energy storage devices that store energy in the form of chemical potential through redox reactions such as lithium‐ion batteries (LIBs) have drawn increasing attention. [ 1‐8 ] Conventional commercial LIBs use graphite and transition metal oxide, respectively, as the anode and cathode materials, which however are reaching their electrochemical performance limits and may cause environmental pollution and resource consumption. [ 9 ] In fact, the performance of LIBs is more related to the cathode materials.…”

Tuning Energy Transfer in Metal‐Organic Frameworks for Fluorescence Turn‐on Sensing of Hg(II) Ions†

“…Metal‐organic frameworks [ 1‐3 ] are a class of hybrid porous materials constructed from organic linkers and inorganic metal ions or clusters via coordination bonds. Owing to their excellent crystallinity, high surface areas, and tunable pore structure and functional properties, MOFs have been demonstrated to be useful in a broad range of research areas, such as molecular adsorption and separation, [ 4‐10 ] energy devices, [ 11‐15 ] drug delivery, [ 16‐20 ] sensing, [ 21‐26 ] and so on. Luminescent MOFs, [ 27‐44 ] a subclass of functional MOFs, [ 45 ] which are primarily constructed by reticulating luminescent metal ions or/and organic linkers/guests into the frameworks, have been well applied for diversifying the potential optoelectronic applications of MOFs.…”

“…With these considerations in mind, we herein designed and synthesized a novel FRET‐based acceptor molecule, in which the 1,3‐dithiol‐2‐thione unit can be oxidized by Hg(II) ions and thus exhibit tunable absorption properties. After reacting with zirconium salt in presence of the selected amount of fluorescent donor, a series of MOFs [UiO‐68‐DT( x ), x = 1.1, 3.4, 7.0, 10.3] with variable ratios of donor and acceptor in the frameworks (Scheme 1) were constructed. As expected, the FRET processes in the MOFs efficiently lead to very weak luminescent properties.…”

A Rational Design of Metal–Organic Framework Nanozyme with High-Performance Copper Active Centers for Alleviating Chemical Corneal Burns

“…As the most prominent representatives of artificial enzymes, nanozymes have shown a wide range of applications from in vitro assays to disease treatment by combining their unique physicochemical properties and catalytic activity [ 9 – 16 ]. MOFs are commonly used to construct nanozymes that mimic chemical processes, such as redox reactions catalyzed by biological redox enzymes [ 17 – 19 ]. However, most reported MOFs usually possess relatively low catalytic activity compared with metalloenzymes.…”