2019
DOI: 10.1002/hipo.23166
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Improving fitness increases dentate gyrus/CA3 volume in the hippocampal head and enhances memory in young adults

Abstract: Converging evidence suggests a relationship between aerobic exercise and hippocampal neuroplasticity that interactively impacts hippocampally dependent memory.The majority of human studies have focused on the potential for exercise to reduce brain atrophy and attenuate cognitive decline in older adults, whereas animal studies often center on exercise-induced neurogenesis and hippocampal plasticity in the dentate gyrus (DG) of young adult animals. In the present study, initially sedentary young adults (18-35 ye… Show more

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Cited by 45 publications
(74 citation statements)
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References 89 publications
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“…In young adults specifically, aerobic exercise training that increases cardiorespiratory fitness is associated with increased anterior hippocampal volume (Thomas et al, 2016). This phenomenon may be driven by plasticity of the DG in particular, as neuroimaging studies with subfield‐level precision indicate that increasing cardiorespiratory fitness through aerobic exercise training results in increased DG cerebral blood volume (Pereira et al, 2007) and left anterior DG/CA3 volume (Nauer, Dunne, Stern, Storer, & Schon, 2020). Behaviorally in young adults, studies suggest that increasing cardiorespiratory fitness may enhance mnemonic discrimination task performance (Déry et al, 2013; Nauer, Dunne, et al, 2020).…”
Section: Introductionmentioning
confidence: 99%
“…In young adults specifically, aerobic exercise training that increases cardiorespiratory fitness is associated with increased anterior hippocampal volume (Thomas et al, 2016). This phenomenon may be driven by plasticity of the DG in particular, as neuroimaging studies with subfield‐level precision indicate that increasing cardiorespiratory fitness through aerobic exercise training results in increased DG cerebral blood volume (Pereira et al, 2007) and left anterior DG/CA3 volume (Nauer, Dunne, Stern, Storer, & Schon, 2020). Behaviorally in young adults, studies suggest that increasing cardiorespiratory fitness may enhance mnemonic discrimination task performance (Déry et al, 2013; Nauer, Dunne, et al, 2020).…”
Section: Introductionmentioning
confidence: 99%
“…Exercise-induced increases in hippocampal volume, measured by MRI, have been previously described in mice [30,31] and humans [11,[32][33][34][35]. In addition, such increases have been correlated with exercise levels in humans [12,13,36], suggesting a dose-response effect. Our findings on hippocampal volume are in line with these results, indicating that our study design was sufficient to produce and evaluate exercise-induced neuroplasticity in the hippocampus.…”
Section: Discussionmentioning
confidence: 81%
“…Rodent models investigating neuroplasticity in the hippocampus show that exercise increases dendritic complexity; raises the number of dendritic spines; enhances synaptic plasticity; improves de novo neurogenesis, angiogenesis, and cerebral blood volume in the dentate gyrus; and elevates oligodendrocyte precursor proliferation [4][5][6][7][8][9][10]. In humans, exercise increases both hippocampal volume and cerebral blood flow to the hippocampus [7,[11][12][13]. higher physical activity levels are associated with improved global white matter (WM) outcomes, including expanded WM volume, smaller WM lesions, and better WM microstructure [14].…”
Section: Introductionmentioning
confidence: 99%
“…We found both the hippocampus and DG of TSK-KO mouse brain were reduced in size. Reduced size of hippocampus and DG are reported to induce memory loss and associate with multiple neuronal disorders (Erickson et al, 2011;Honea et al, 2009;Nauer, Dunne, Stern, Storer, & Schon, 2019).…”
Section: Discussionmentioning
confidence: 99%