Improving Feedability of Highly Adhesive Active Pharmaceutical Ingredients by Silication

Escotet‐Espinoza, M. Sebastian; Scicolone, James V.; Moghtadernejad, Sara; Sánchez, Eric; Cappuyns, Philippe; Assche, Ivo Van; Pretoro, G. Di; Ierapetritou, Marianthi G.; Muzzio, Fernando J.

doi:10.1007/s12247-020-09448-y

Cited by 7 publications

(17 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…at is, the coordinate value of the collection point and the collected RSSI vector value and the RSSI vector value collected by the positioning terminal at the point to be measured are used as the input value of the multidimensional scaling algorithm [24]. e relative coordinates of the terminal point to be measured are estimated by using this algorithm.…”

Section: Stressmentioning

confidence: 99%

Cultivation of Innovative Ability of College Physical Education Students Based on the Internet of Things Multimedia Environment

Cai

2022

International Transactions on Electrical Energy Systems

View full text Add to dashboard Cite

Innovation is the source of social progress, and all walks of life need to cultivate innovative talents. Therefore, it is also very important to cultivate innovative ability in physical education students in colleges and universities. The purpose of this paper is to study the cultivation of students’ innovative ability of physical education majors in colleges and universities based on the multimedia environment of the Internet of things and to open up a new path for the cultivation of college students’ innovative ability. In this paper, a terminal collaborative indoor positioning algorithm based on RSSI fingerprint optimization was proposed to study the innovation ability of physical education students in colleges and universities. Through experimental analysis, college A was taken as the research object, and 1500 students were investigated. Innovation had a very important position in the hearts of 76.21% of students, and 3.83% of students believed that innovation was not important. In the minds of most people, innovation was still very important, which showed that schools still had a certain effect on the education of students’ innovative consciousness. The experimental results obtained showed that the Internet of things technology played an important role in the research on the innovation ability of students majoring in physical education in colleges and universities.

show abstract

Section: Stressmentioning

confidence: 99%

Cultivation of Innovative Ability of College Physical Education Students Based on the Internet of Things Multimedia Environment

Cai

2022

International Transactions on Electrical Energy Systems

View full text Add to dashboard Cite

show abstract

“…Recently, Escotet-Espinoza et al [ 40 ] demonstrated the effectiveness of blending two APIs with ffc values of 3 and 4 with 1% silica and thereby improving the ffc to 11 and 35 respectively. Towards the same goal, Todorova [ 41 ] showed that hydrophobisizing the surfaces of particles can decrease the free surface energy and minimize the effect of capillary forces.…”

Section: Modeling Of Batch Processesmentioning

confidence: 99%

Direct Compaction Drug Product Process Modeling

et al. 2022

View full text Add to dashboard Cite

Most challenges during the development of solid dosage forms are related to the impact of any variations in raw material properties, batch size, or equipment scales on the product quality and the control of the manufacturing process. With the ever pertinent restrictions on time and resource availability versus heightened expectations to develop, optimize, and troubleshoot manufacturing processes, targeted and robust science-based process modeling platforms are essential. This review focuses on the modeling of unit operations and practices involved in batch manufacturing of solid dosage forms by direct compaction. An effort is made to highlight the key advances in the past five years, and to propose potentially beneficial future study directions.

show abstract

“…Powder cohesion refers to the affinity of particles to adhere to each other. It manifests in the bulk as resistance to powder flow often accompanied by adhesive behaviour, which refers to the tendency of a material to bind to surfaces and other materials [ 6 ]. Factors which contribute to cohesion include: Liquid bridges (liquid bridges will not be discussed in this literature review as there already exist comprehensive reviews of this topic [ 7 , 8 , 9 ]).…”

Section: Introductionmentioning

confidence: 99%

“…Active pharmaceutical ingredients (APIs) are typically the components of tablet formulations that give rise to handling issues, due to their often very high cohesivity, low bulk density, and highly aspherical geometries, in turn resulting in undesirable operating performance for CDC [ 6 , 18 ]. Many APIs are needle-like and very fine (<10

m) resulting in a high contact area and cohesion (and thus poor flowability), whereas excipients are typically coarser and have a more favourable (spherical) particle shape, leading to better flowability.…”

Section: Introductionmentioning

confidence: 99%

“…In some instances, moderate cohesion has been found to aid the proper functioning of a given unit operation. For example, during powder feeding the addition of nano-sized silica was shown to result in reduced adhesion to feeder surfaces and improved powder flow as will be discussed later in this review [ 6 , 22 ]. However, in most cases of high cohesivity, flow is inhibited [ 23 , 24 ], which is problematic for feeding [ 25 ], mixing [ 26 ] and die filling [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Reviewing the Impact of Powder Cohesion on Continuous Direct Compression (CDC) Performance

et al. 2023

View full text Add to dashboard Cite

The pharmaceutical industry is undergoing a paradigm shift towards continuous processing from batch, where continuous direct compression (CDC) is considered to offer the most straightforward implementation amongst powder processes due to the relatively low number of unit operations or handling steps. Due to the nature of continuous processing, the bulk properties of the formulation will require sufficient flowability and tabletability in order to be processed and transported effectively to and from each unit operation. Powder cohesion presents one of the greatest obstacles to the CDC process as it inhibits powder flow. As a result, there have been many studies investigating potential manners in which to overcome the effects of cohesion with, to date, little consideration of how these controls may affect downstream unit operations. The aim of this literature review is to explore and consolidate this literature, considering the impact of powder cohesion and cohesion control measures on the three-unit operations of the CDC process (feeding, mixing, and tabletting). This review will also cover the consequences of implementing such control measures whilst highlighting subject matter which could be of value for future research to better understand how to manage cohesive powders for CDC manufacture.

show abstract

Improving Feedability of Highly Adhesive Active Pharmaceutical Ingredients by Silication

Cited by 7 publications

References 50 publications

Cultivation of Innovative Ability of College Physical Education Students Based on the Internet of Things Multimedia Environment

Cultivation of Innovative Ability of College Physical Education Students Based on the Internet of Things Multimedia Environment

Direct Compaction Drug Product Process Modeling

Reviewing the Impact of Powder Cohesion on Continuous Direct Compression (CDC) Performance

Contact Info

Product

Resources

About