Improving effect of dietary soybean phospholipids supplement on hepatic and serum indexes relevant to fatty liver hemorrhagic syndrome in laying hens

Abstract

In order to investigate the effect of dietary soybean phospholipid supplement on hepatic and serum indexes relevant to fatty liver hemorrhagic syndrome (FLHS) in layers, 135 300-day-old Hyline Brown layers were randomly divided into three groups (control, pathology and prevention), and each group had 45 layers with three replicates. Birds in the three groups were respectively fed the control diet, high-energy low-protein diet and high-energy high-protein diet affixed with 3% soybean phospholipid instead of maize. Results showed in the 30th day, birds' livers in the pathology group became yellowish, enlarged in size and had hemorrhagic spots, while the prevention and control groups' layers did not have such pathological changes. Contents of triglyceride, total cholesterol, low-density lipoprotein - cholesterol, non-esterified fatty acid and malondialdehyde in serum or liver homogenate in prevention and control groups were remarkably lower than those in the pathology group (P < 0.05 or P < 0.01), as with the activities of glutamic oxalacetic transaminase and glutamic-pyruvic transaminase (P < 0.01); high-density lipoprotein - cholesterol value was strikingly higher than that of the pathology group (P < 0.01). It is suggested dietary soybean phospholipids supplement may effectively improve hepatic and blood indexes relevant to FLHS, which provides a new point for preventing FLHS occurrence rate in laying flocks and treating human non-alcohol fatty liver disease.

Effects of a high energy and low protein diet on hepatic and plasma characteristics and Cidea and Cidec mRNA expression in liver and adipose tissue of laying hens with fatty liver hemorrhagic syndrome

“…Analysis of the liver by tissue sectioning and H&E staining further showed that the HELP diet induced micro‐vesicular steatosis in the layers, which indicated that FLHS successfully occurred in experimental group. The results were also supported by previous studies (Song et al., ; Trott et al., ; Yang et al., ; Zhang, Chen, Yu, & Wang, ). It was thought that high‐energy intake caused increased fatty acids in plasma, furthering an elevated level of lipogenesis in the liver, which leaded to TG accumulation in the liver and then the occurrence of FLHS (Whitehead, ).…”

“…Nutritional and genetic factors, feeding methods, environmental conditions, toxic substances, and hormones all contribute to the occurrence of this syndrome (Butler, ; Choi et al., ; Hansen & Walzem, ; Polin & Wolford, ; Schuman, Squires, & Leeson, ; Squires & Leeson, ; Zhu et al., ), whereas nutrition is the major factor in current poultry industry. Recently some studies reported that a HELP diet successfully induced FLHS in laying hens (Song et al., ; Yang et al., ). The HELP diet was also reported as a natural cause of FLHS (Rozenboim et al., ).…”

“…Wolford and Polin reported over consumption of energy would appear to be related because excessive food intake has been observed to result in liver hemorrhages characteristic of FLHS (Wolford & Polin, ). Recently, some studies also reported that a high‐energy low‐protein (HELP) diet induced FLHS model successfully (Jiang, Cheng, Cui, Zhou, & Hou, ; Rozenboim, Mahato, Cohen, & Tirosh, ; Song et al., ; Yang et al., ).…”

Insulin resistance and metabonomics analysis of fatty liver haemorrhagic syndrome in laying hens induced by a high-energy low-protein diet

“…Fatty liver haemorrhagic syndrome (FLHS) is a nutritional and metabolic disease characterized by a lipid metabolism disorder that is harmful to the development of the layer breeding industry 1–3 . Due to the adoption of caged feeding technology and advances in breeding in the layer industry, FLHS, which is commonly observed, has periods of latency and sudden outbreaks, causing a sudden drop in egg production.…”

Fatty Liver Haemorrhagic Syndrome (FLHS) in Broilers

“…Higher incidence of FLHS was reported due to consumption of chelated minerals in hen than those consumed non-chelated minerals. Dietary soyabean phospholipids have been found to improve hepatic and blood lipid profile indexes relevant to FLHS (Yang et al, 2017). Dietary supplement of lipotropic agents containing choline were found helpful for remedy of FLHS (Onel et al, 2017).…”