Improving DNA nanostructure stability: A review of the biomedical applications and approaches

Nasiri, Mahboobeh; Bahadorani, Mehrnoosh; Dellinger, Kristen; Aravamudhan, Shyam; Vivero-Escoto, Juan L.; Zadegan, Reza

doi:10.1016/j.ijbiomac.2024.129495

Cited by 5 publications

(1 citation statement)

References 169 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence of conjugated double bonds in FA acyls alters the physical properties of lipids containing them, which may help algae and higher plants adapt to demanding environments (for example, by dissipating intense light flux in high-altitude terrains [ 2 ]). Conjugated FAs appear to be a viable building material for liposome synthesis, which, in addition to their fundamental applications [ 3 ], are being intensively studied as transporters for targeted drug delivery [ 4 ], including cancer treatment [ 5 ]. Conjugated linoleic acid (CLA) has various advantages over common unsaturated FAs [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of Conjugated Dienes of Fatty Acids in Vischeria sp. IPPAS C-70 under Oxidative Stress

Sidorov,

Starikov,

Sinetova

et al. 2024

IJMS

View full text Add to dashboard Cite

The microalgae Vischeria sp. IPPAS C-70 produces eicosapentaenoic acid. Several stresses cause the formation of fatty acid peaks that resemble hexadecadienoic acids. We used the integrated technique including TLC, HPLC, and GC–MS to search and determine these fatty acids. Double bond positioning in these fatty acids indicated that they were conjugated dienes and allenes. We identified and described natural nine isomers of C16 polyunsaturated fatty acids, including common methylene-interrupted dienes (Δ6,9-16:2, Δ7,10-16:2, Δ9,12-16:2), and unusual conjugated dienes (Δ6,8-, Δ7,9-, Δ8,10-, Δ9,11-, and Δ10,12-16:2), as well as allenic diene (Δ9,10-16:2). We hypothesize that the formation of conjugated dienes and allenes among fatty acids is the result of oxidative stress caused by H2O2. Hydrogen peroxide also caused an increase in saturated at the expense of unsaturated fatty acids, suggesting inhibition either fatty acid desaturases activities or the corresponding gene expression.

show abstract