Improving Crystal Morphology through Cocrystallization: A Case Study of Rufinamide-Trimesic Acid Cocrystal
Soroush Ahmadi,
Bernhard Spingler,
Sohrab Rohani
Abstract:Crystal morphology plays a pivotal role in the production process of pharmaceutical compounds and influences the properties of the final product. Achieving control over crystal morphology, especially for thin and needle-like crystals, presents significant challenges to the industry. In this study, we investigate the crystal morphology of rufinamide (RUF) as a model compound with a notorious thread-like morphology. RUF polymorphs crystallize with markedly poor aspect ratios, with the most stable form (form A) e… Show more
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