Improving calcium citrate food functions through spherulitic growth in reactive crystallization and a mechanism study

Yan, Hui; Liu, Yanbo; Hao, Peng; Li, Kangli; Li, Chengwei; Jiang, Shuixing; Chen, Mingyang; Han, Dandan; Gong, Junbo

doi:10.1016/j.foodchem.2022.134550

Cited by 13 publications

(18 citation statements)

References 39 publications

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“…66 However, excessively high stirring rates can damage the spherulitic structure due to the intense shear forces involved. 64,66,109 3.2. Technologies for Multicomponent Spheres.…”

Section: Effects Of Temperaturementioning

confidence: 99%

“…It is reported that stirring is beneficial to the formation of spherulite by accelerating secondary nucleation and enhancing the non-crystallographic branching frequency of crystals. , Stirring also facilitates solute diffusion, leading to relatively higher supersaturation near the interface, which promotes branching . However, excessively high stirring rates can damage the spherulitic structure due to the intense shear forces involved. ,, …”

Section: Spherical Crystallization Technologies For Drugsmentioning

confidence: 99%

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Particle Design of Drugs via Spherical Crystallization: A Review from Fundamental Aspects to Technology Development

Sun,

Bi,

Zhao

et al. 2024

Crystal Growth & Design

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In the pharmaceutical industry, the production process of most active pharmaceutical ingredients involves at least one crystallization step. Design of drug spheres via various spherical crystallization technologies can impart crystals with certain superior attributes including high flowability and compressibility as well as excellent mechanical properties. Some new spherical crystallization approaches and design principles have been proposed in recent years. This review aims to review the up-to-date design principles and preparation technologies of drug spheres, providing a guide for design, preparation, and performance evaluation of the drug spheres. Herein, we review the mechanisms and design principles of the spherical crystallization first, and subsequently various technologies reported in the literature are reviewed with the critical process parameters being analyzed. Lastly, the challenges facing the development of spherical crystallization for drugs are discussed.

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“…66 However, excessively high stirring rates can damage the spherulitic structure due to the intense shear forces involved. 64,66,109 3.2. Technologies for Multicomponent Spheres.…”

Section: Effects Of Temperaturementioning

confidence: 99%

Section: Spherical Crystallization Technologies For Drugsmentioning

confidence: 99%

Particle Design of Drugs via Spherical Crystallization: A Review from Fundamental Aspects to Technology Development

Sun,

Bi,

Zhao

et al. 2024

Crystal Growth & Design

Self Cite

View full text Add to dashboard Cite

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“…The filtration properties of the crystal samples were evaluated by a procedure reported previously . Briefly, the procedure involved weighing 5 g of solid products and adding them to 200 g of water, which was then filtered under a pressure of −0.025 MPa by using a vacuum pump.…”

Section: Experimental Sectionmentioning

confidence: 99%

“…The filtration properties of the crystal samples were evaluated by a procedure reported previously. 28 Briefly, the procedure involved weighing 5 g of solid products and adding them to 200 g of water, which was then filtered under a pressure of −0.025 MPa by using a vacuum pump. Filtration time was recorded using a timer, and the measurement of each crystal sample was performed in triplicate with an average value and standard deviations reported.…”

Section: Thermogravimetric Analysis (Tga)mentioning

confidence: 99%

Development Strategies of Polymorphs and Solvates for Enhancing Powder Properties: A Case Study of Thiothiamine

Han,

Qu,

et al. 2023

Crystal Growth & Design

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Crystals with an acicular shape are a "nightmare" to many chemical engineers due to their poor powder properties, posing numerous challenges in purification, filtration, washing, and subsequent processing. However, these challenges may be circumvented by engineering new crystal forms with better morphology using a crystal engineering strategy. Herein, we demonstrated the validity of this strategy with the case of thiothiamine, an essential intermediate in the production of vitamin B1, which exhibits a needle-like crystal morphology in polymorph I. Another two polymorphs (forms II and III) and 14 solvates were discovered and developed using a combination of computational prediction and experimental screening with X-ray diffraction, IR spectroscopy, and thermal analysis. Crystal structures of form II and six solvates were fully determined for the first time by single crystal X-ray diffraction. First, compared to form I, form II exhibits a notably larger grain size. Furthermore, the desolvation of solvates can retain its original superior morphology. These optimization strategies targeting crystal morphology directly contribute to the enhancement of the powder performance. Specifically, the filtration time was significantly reduced by over 70%, and the flowability of the powder was also greatly improved. Crystal structure analysis reveals that inclusion of small solvent molecules in a disordered manner contributes to solvate formation, while hydrogen bonding interactions contribute to the formation of methanol solvate. This study can serve as a valuable reference for addressing filtration and flowability challenges in industry by using crystal engineering strategies to develop polymorph or solvate alternatives.

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“…In addition, they successfully manipulated the crystal aspect ratio by adjusting solvent content, accomplishing the production of large crystals that had never been achieved through single-phase crystallization methods . Moreover, oiling-out crystallization holds potential for creating spherulites that exhibit favorable characteristics, such as excellent flowability and compressibility (pharmaceuticals), anticaking properties and functional effectiveness (food), outstanding packability and stability (fertilizers), as well as enhanced mechanical properties and safety (explosives). , Veesler et al. capitalized on the nucleation of droplets to introduce a spherical crystallization method, which paved the way for further studies on the optimization of the oiling-out process .…”

Section: Introductionmentioning

confidence: 99%

Microfluidic Crystallization for Screening of Spherical Particles of Pyraclostrobin

Zhong,

Guo,

Bao

2024

Ind. Eng. Chem. Res.

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The semicontinuous antisolvent crystallization process of pyraclostrobin was investigated utilizing an integrated microfluidic device that encompasses both microfluidic channels and an agitated crystallizer. We successfully regulated the crystal morphology as quasi-spherical particles and narrowed the particle size distribution compared with that of the raw materials. We explored the impact of ultrasound powers, initial concentration, antisolvent content, and stirring rate on crystal morphology. Our innovative approach involves precisely manipulating the stirring rate and solvent content, resulting in diverse crystal morphologies. Notably, we unveil two distinct mechanisms governing the formation of spherical particles, which can be attributed to the variability in the oil droplet sizes. Our apparatus and approach enable the efficient screening of spherical particles, advocating minimal reagent consumption. This achievement holds the potential to be scaled across a variety of fields ranging from pharmaceuticals to material science.

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Improving calcium citrate food functions through spherulitic growth in reactive crystallization and a mechanism study

Cited by 13 publications

References 39 publications

Particle Design of Drugs via Spherical Crystallization: A Review from Fundamental Aspects to Technology Development

Particle Design of Drugs via Spherical Crystallization: A Review from Fundamental Aspects to Technology Development

Development Strategies of Polymorphs and Solvates for Enhancing Powder Properties: A Case Study of Thiothiamine

Microfluidic Crystallization for Screening of Spherical Particles of Pyraclostrobin

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