Improving bone regeneration with composites consisting of piezoelectric poly(l-lactide) and piezoelectric calcium/manganese co-doped barium titanate nanofibers

Zheng, Tianyi; Yu, Yingjie; Pang, Yanyun; Zhang, Daixing; Wang, Yue; Zhao, Hongyang; Zhang, Xu; Leng, Huijie; Yang, Xiaoping; Cai, Qing

doi:10.1016/j.compositesb.2022.109734

Cited by 52 publications

(34 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was obvious to see that the expressions of the proinflammatory cytokine genes including TNF-α, CD86, and IL-6 were significantly downregulated on BTCP+ and BTCP–. It may conclude that the polarized charges have some suppression effect on the conversion of macrophages to the M1 phenotype . On the one hand, proinflammatory cytokine genes CD86, IL-18, and IL-6 were obviously downregulated on BTCP+, as compared to BTCP–, which indicated that the polarized positive charges more effectively alleviated the inflammatory reaction.…”

Section: Resultsmentioning

confidence: 95%

Enhanced Cell Osteogenesis and Osteoimmunology Regulated by Piezoelectric Biomaterials with Controllable Surface Potential and Charges

Mao

Bai

Wang

et al. 2022

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Bone regeneration is a well-orchestrated process involving electrical, biochemical, and mechanical multiple physiological cues. Electrical signals play a vital role in the process of bone repair. The endogenous potential will spontaneously form on defect sites, guide the cell behaviors, and mediate bone healing when the bone fracture occurs. However, the mechanism on how the surface charges of implant potentially guides osteogenesis and osteoimmunology has not been clearly revealed yet. In this study, piezoelectric BaTiO3/β-TCP (BTCP) ceramics are prepared by two-step sintering, and different surface charges are established by polarization. In addition, the cell osteogenesis and osteoimmunology of BMSCs and RAW264.7 on different surface charges were explored. The results showed that the piezoelectric constant d33 of BTCP was controllable by adjusting the sintering temperature and rate. The polarized BTCP with a negative surface charge (BTCP−) promoted protein adsorption and BMSC extracellular Ca2+ influx. The attachment, spreading, migration, and osteogenic differentiation of BMSCs were enhanced on BTCP–. Additionally, the polarized BTCP ceramics with a positive surface charge (BTCP+) significantly inhibited M1 polarization of macrophages, affecting the expression of the M1 marker in macrophages and changing secretion of proinflammatory cytokines. It in turn enhanced osteogenic differentiation of BMSCs, suggesting that positive surface charges could modulate the bone immunoregulatory properties and shift the immune microenvironment to one that favored osteogenesis. The result provides an alternative method of synergistically modulating cellular immunity and the osteogenesis function and enhancing the bone regeneration by fabricating piezoelectric biomaterials with electrical signals.

show abstract

Section: Resultsmentioning

confidence: 95%

Enhanced Cell Osteogenesis and Osteoimmunology Regulated by Piezoelectric Biomaterials with Controllable Surface Potential and Charges

Mao

Bai

Wang

et al. 2022

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…Among the newest studied materials, Mg-Zn, PLLA, and tungsten disulfide nanoparticles (WS 2 ) have shown promising outcomes. [256][257][258] Natural polymers (such as collagen, gelatin, silk fibroin, and chitosan) and synthetic polymers (such as PLA, PGA, and PCL) are the most common bioresorbable biomaterials used in bone tissue engineering (such as HA, b-TCP, and BGs). Because of their outstanding bone regeneration potential, scaffolds incorporating additives (such as growth factors) have been used in clinical applications.…”

Section: Composite Smart Biomaterials For Bone Tissue Engineeringmentioning

confidence: 99%

Smart biomaterials and their potential applications in tissue engineering

et al. 2022

View full text Add to dashboard Cite

show abstract

“…For example, a report shows (ref. 5 in Table S3, ESI †) active layer preparation by polymer, ceramic and conducting filler additions. If our idea of a grain size optimized ceramic is utilized in their strategy, the device performance will increase further.…”

Section: Mechanical Energy Harvesting and Sensing Behavior Of The Com...mentioning

confidence: 99%

“…Converting mechanical energy to electrical energy has multiple benefits. These include potential replacement of batteries for low power electronic devices operating at remote locations, 1,2 stress/strain sensors for probing device functionality, 3,4 tissue regeneration, 5 environmental remediation, 6 etc. Two widely studied methods to harvest mechanical motions are triboelectric energy harvesting (TEH) [7][8][9][10] and piezoelectric energy harvesting (PEH).…”

Section: Introductionmentioning

confidence: 99%

A high performance piezoelectric–triboelectric hybrid energy harvester by synergistic design

Khatua

Kim

2022

Energy Adv.

View full text Add to dashboard Cite

show abstract

Improving bone regeneration with composites consisting of piezoelectric poly(l-lactide) and piezoelectric calcium/manganese co-doped barium titanate nanofibers

Cited by 52 publications

References 62 publications

Enhanced Cell Osteogenesis and Osteoimmunology Regulated by Piezoelectric Biomaterials with Controllable Surface Potential and Charges

Enhanced Cell Osteogenesis and Osteoimmunology Regulated by Piezoelectric Biomaterials with Controllable Surface Potential and Charges

Smart biomaterials and their potential applications in tissue engineering

A high performance piezoelectric–triboelectric hybrid energy harvester by synergistic design

Contact Info

Product

Resources

About