Improving attrition rates in Ebola virus drug discovery

Glišić, Sanja; Paessler, Slobodan; Veljković, Nevena; Perovic, Vladimir; Prljić, Jelena; Veljković, Veljko

doi:10.1517/17460441.2015.1062872

Cited by 4 publications

(1 citation statement)

References 39 publications

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“…Recently, several studies in silico, in vitro and in vivo were carried out for repurposing of approved drugs for prevention and treatment of the Ebola disease (8). The AQVN and EIIP values calculated for drugs selected in these studies are given in Table 1.…”

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confidence: 99%

Ibuprofen as a template molecule for drug design against Ebola virus

et al. 2018

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The Ebola virus outbreak in West Africa 2015 and Congo 2017, point out an urgent need for development of drugs against this important pathogen. Previously, by repurposing virtual screening of 6438 drugs from DrugBank, ibuprofen was selected as a possible inhibitor of the Ebola virus infection. The results of an additional docking analysis as well as experimental results showing measurable anti-Ebola effect of ibuprofen in cell culture suggest ibuprofen as a promising molecular template for the development of drugs for treatment of the infection by Ebola virus.

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confidence: 99%

Ibuprofen as a template molecule for drug design against Ebola virus

et al. 2018

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Therapeutics Against Filovirus Infection

Connor

Kobinger

Olinger

2017

Current Topics in Microbiology and Immunology

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Therapies for filovirus infections are urgently needed. The paradoxical issue facing therapies is the need for rigorous safety and efficacy testing, adhering to the principle tenant of medicine to do no harm, while responding to the extreme for a treatment option during an outbreak. Supportive care remains a primary goal for infected patients. Years of research into filoviruses has provided possible medical interventions ranging from direct antivirals, host-factor supportive approaches, and passive immunity. As more basic research is directed toward understanding these pathogens and their impact on the host, effective approaches to treat patients during infection will be identified. The ability to manage outbreaks with medical interventions beyond supportive care will require clinical trial design that will balance the benefits of the patient and scientific community.

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Contrasting academic and lay press print coverage of the 2013-2016 Ebola Virus Disease outbreak

2017

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Under a traditional paradigm, only those with the expected background knowledge consume academic literature. The lay press, as well as government and non-government agencies, play a complementary role of extracting findings of high interest or importance and translating them for general viewing. The need for accurate reporting and public advising is paramount when attempting to tackle epidemic outbreaks through behavior change. Yet, public trust in media outlets is at a historic low. The Crisis and Emergency Risk Communication (CERC) model for media reporting on public health emergencies was established in 2005 and has subsequently been used to analyze media reporting on outbreaks of influenza and measles as well as smoking habits and medication compliance. However, no media analysis had yet been performed on the 2013–2016 Ebola Virus Disease (EVD) outbreak. This study compared the EVD information relayed by lay press sources with general review articles in the academic literature through a mixed-methods analysis. These findings suggest that comprehensive review articles could not serve as a source to clarify and contextualize the uncertainties around the EVD outbreak, perhaps due to adherence to technical accuracy at the expense of clarity within the context of outbreak conditions. This finding does not imply inferiority of the academic literature, nor does it draw direct causation between confusion in review articles and public misunderstanding. Given the erosion of the barriers siloing academia, combined with the demands of today’s fast-paced media environment, contemporary researchers should realize that no study is outside the public forum and to therefore consider shifting the paradigm to take personal responsibility in the process of accurately translating their scientific words into public policy actions to best serve as a source of clarity.

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Improving attrition rates in Ebola virus drug discovery

Cited by 4 publications

References 39 publications

Ibuprofen as a template molecule for drug design against Ebola virus

Ibuprofen as a template molecule for drug design against Ebola virus

Therapeutics Against Filovirus Infection

Contrasting academic and lay press print coverage of the 2013-2016 Ebola Virus Disease outbreak

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