Improving Alzheimer's disease by altering gut microbiota in tree shrews with ginsenoside Rg1

Wang, Limei; Lu, Jiangli; Zeng, Yaqiong; Guo, Yuqian; Wu, Chao; Zhao, Hongbin; Zheng, Hong; Jiao, Jianlin

doi:10.1093/femsle/fnaa011

Cited by 33 publications

(23 citation statements)

References 33 publications

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“…The associations between microbiota and dementia have been supported in numerous studies [52][53][54][55][56][57][58]. H. pylori is suggested as the main microbiota associated with cognitive impairment [3].…”

Section: Discussionmentioning

confidence: 85%

Helicobacter Pylori Infection is Associated With Neurodegeneration in Cognitively Normal Males

Park

Kim

Song

et al. 2020

Preprint

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Background An association between Helicobacter pylori (H. pylori) infection and dementia was reported in previous studies, however, the evidence is inconsistent. In the present study, the association between H. pylori infection and brain cortical thickness as a biomarker of neurodegeneration was investigated. Methods A cross-sectional study of 1,446 healthy adults who underwent a medical health check-up, including an esophagogastroduodenoscopy and 3.0 T magnetic resonance imaging was performed. H. pylori infection status was assessed based on histology. Multiple linear regression analysis was conducted to evaluate the relationship between H. pylori infection and brain cortical thickness. Results Males with H. pylori infection exhibited cortical thinning in the bilateral lateral temporal, lateral frontal, and right occipital areas compared with non-infected males after controlling for age, educational level, alcohol intake, smoking status, and intracranial volume. The association remained significant after further adjusting for inflammatory marker (C-reactive protein) and metabolic factors (obesity, dyslipidemia, fasting glucose, and blood pressure). However, an association between H. pylori infection and brain cortical thickness was not observed in females. Conclusions The findings indicate H. pylori infection is associated with neurodegenerative changes in cognitive normal males, independent of chronic inflammation or metabolic syndrome.

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Section: Discussionmentioning

confidence: 85%

Helicobacter Pylori Infection is Associated With Neurodegeneration in Cognitively Normal Males

Park

Kim

Song

et al. 2020

Preprint

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“…A positive correlation between Verrucomicrobia level and cognitive functions was noted for the neurologically-healthy older adult people [ 61 ]. Increases in Verrucomicrobia level suppress neurodegeneration [ 62 ]. Verrucomicrobia reverses cognitive dysfunction including impaired spatial working memory and recognition of new objects, restores brain metabolism [ 63 ], and alleviates memory impairment caused by high fat in mice [ 64 ].…”

Section: Discussionmentioning

confidence: 99%

Nrf2/ARE Activators Improve Memory in Aged Mice via Maintaining of Mitochondrial Quality Control of Brain and the Modulation of Gut Microbiome

et al. 2021

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Aging is one of the most serious factors for central nervous dysfunctions, which lead to cognitive impairment. New highly effective drugs are required to slow the development of cognitive dysfunction. This research studied the effect of dimethyl fumarate (DMF), methylene blue (MB), and resveratrol (RSV) on the cognitive functions of 15-month-old mice and their relationship to the maintenance of mitochondrial quality control in the brain and the bacterial composition of the gut microbiome. We have shown that studied compounds enhance mitochondrial biogenesis, mitophagy, and antioxidant defense in the hippocampus of 15-month-old mice via Nrf2/ARE pathway activation, which reduces the degree of oxidative damage to mtDNA. It is manifested in the improvement of short-term and long-term memory. We have also shown that memory improvement correlates with levels of Roseburia, Oscillibacter, ChristensenellaceaeR-7, Negativibacillus, and Faecalibaculum genera of bacteria. At the same time, long-term treatment by MB induced a decrease in gut microbiome diversity, but the other markers of dysbiosis were not observed. Thus, Nrf2/ARE activators have an impact on mitochondrial quality control and are associated with a positive change in the composition of the gut microbiome, which together lead to an improvement in memory in aged mice.

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“…Since SYFSF is a mixture of many chemical substances, from which we identified 21 substances by UHPLC-Q-TOF analysis. Many of these substances have been reported to affect gut microbiota, including Calycosin-7-O-glucoside ( Ruan et al, 2015 ), Ferulic acid ( Ma et al, 2019 ), Ginsenoside Rd ( Han et al, 2020 ), and Ginsenoside Rg1 ( Wang et al, 2020 ). We believe that the beneficial effects of SYFSF are mostly due to remodeling of gut microbiota.…”

Section: Discussionmentioning

confidence: 99%

Modulation of the Gut Microbiota by Shen-Yan-Fang-Shuai Formula Improves Obesity Induced by High-Fat Diets

Wang

Zhou

et al. 2020

Front. Microbiol.

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Obesity and related metabolic disorders are associated with intestinal microbiota dysbiosis, disrupted intestinal barrier and chronic inflammation. Shen-Yan-Fang-Shuai formula (SYFSF) is a traditional Chinese herbal formula composed of Astragali Radix, Radix Angelicae Sinensis, Rheum Officinale Baill, and four other herbs. In this study, we identified that SYFSF treatment prevented weight gain, low-grade inflammation and insulin resistance in high-fat diet (HFD)-fed mice. SYFSF also substantially improved gut barrier function, reduced metabolic endotoxemia, as well as systemic inflammation. Sequencing of 16S rRNA genes obtained from fecal samples demonstrated that SYFSF attenuated HFD-induced gut dysbiosis, seen an decreased Firmicutes to Bacteroidetes ratios. Microbial richness and diversity were also higher in the SYFSF-treated HFD group. Furthermore, similar therapeutic effects and changes in gut microbiota profile caused by SYFSF could be replicated by fecal microbiota transfer (FMT). Taken together, our study highlights the efficacy of SYFSF in preventing obesity and related metabolic disorders. Its therapeutic effect is associated with the modulation of gut microbiota, as a prebiotic.

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Improving Alzheimer's disease by altering gut microbiota in tree shrews with ginsenoside Rg1

Cited by 33 publications

References 33 publications

Helicobacter Pylori Infection is Associated With Neurodegeneration in Cognitively Normal Males

Helicobacter Pylori Infection is Associated With Neurodegeneration in Cognitively Normal Males

Nrf2/ARE Activators Improve Memory in Aged Mice via Maintaining of Mitochondrial Quality Control of Brain and the Modulation of Gut Microbiome

Modulation of the Gut Microbiota by Shen-Yan-Fang-Shuai Formula Improves Obesity Induced by High-Fat Diets

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