Improving Adverse Drug Reaction Reporting in Hospitals

Abstract

This study shows that regular visits by a CRA increases the number of ADRs collected by a Regional Pharmacovigilance Centre. Another interesting consequence was the rise in spontaneous reporting by healthcare professionals following the set-up of this system. Further assessment of this procedure is necessary for the long-term evaluation of its effectiveness.

Effect of An Educational Intervention to Improve Adverse Drug Reaction Reporting in Physicians: A Cluster Randomized Controlled Trial

“…Another intervention, based on educational presentations and monthly reminders, resulted in an increase in spontaneous ADR reporting in hospital settings [22]. Educational sessions plus regular visits by a research assistant increased both the number of ADRs recorded and the number of reporters [23]. The effect achieved by our educational intervention was similar to that obtained by other controlled studies that included physicians in the intervention group [21,22,24].…”

“…The follow-up period was short if compared to those used in other published educational interventions in pharmacovigilance [21][22][23]. Owing to the termination of the collaboration agreement between the two bodies involved (the university and ADR adverse drug reaction, CI confidence interval, RR relative risk *RR for the two 4-month intervals is the adjusted RR of ADR reporting between the pre-intervention period and the two 4-month intervals of the post-intervention period in the control group.…”

Impact of a pharmacist-driven pharmacovigilance system in a secondary hospital in the Gauteng Province of South Africa

“…HCPs should consider ADR reporting as an obligation [29], especially in view of their potential impact on outcomes and costs, which can be appreciably reduced with improved medicine management [3][4][5]. At Sebokeng Hospital, 98% of HCPs now indicated that it was necessary to report ADRs, similar to the findings from a tertiary hospital in India (97%) [30].…”

Use of case–time–control design in pharmacovigilance applications: exploration with high‐risk medications and unplanned hospital admissions in the Western Australian elderly

“…4 In the USA, ADEs account for nearly 100 000 emergency hospitalisations each year in this age group. 5 Different approaches exist for estimating medication harm resulting in hospitalisation, such as medical record reviews, [6][7][8][9][10][11][12] analysis of spontaneous reporting data, [13][14][15][16][17][18][19] and identification of ADE-related codes from the International Classification of Diseases (ICD) on inpatient records. [20][21][22][23][24][25][26] Some of these methods are labour-intensive, whereas others are subject to under-reporting and selection bias.…”