Improvements in the Effectiveness of Early Detection in Colorectal Cancer with Open-Label Randomised Study

Abstract

Introduction: The general objective of this research is to improve the quality of colorectal cancer screening (CRC) by assessing, as an indicator of effectiveness, the ability of colonoscopy to detect more advanced adenomas in the exposed group than in the control group. Material and Methods: The present work is designed as an open-label randomized study on cancer screening, using two groups based on their exposure to the protocol: an exposed to intervention group (EIG, 167), and a control group (CG, 167), without the intervention of the protocol and by 1:1 matching. Results: In 167 patients in the GEI, 449 polyps are visualized and 274 are adenomas (80.58%), of which 100 (36.49%) are advanced adenomas. In the CG (n = 174), there are 321 polyps and 152 adenomas (82.60%). The variables significantly associated by logistic regression to the detection of adenomas are the male sex with an OR of 2.52. The variable time to withdrawal, ≥9 min, is significant at 99% confidence (p = 0.002/OR 34.67) and the fractional dose is significant at 99% (p = 0.009, OR 7.81). Conclusion: Based on the observations made, our study suggests that the intervention in collaboration between primary care and hospital care is effective from a preventive point of view and achieves the objective of effectiveness and quality of the PCCR.

Epidemiological Situation of High-Prevalence Non-Communicable Diseases in Spain: A Systematic Review

“…Another analysis showed the importance of following an intervention protocol in collaboration with a multidisciplinary team in the search for better outcomes and survival for patients suffering from CRC. In this study, the intervention applied reached 72.41%, which is a high value for the efficiency and efficacy applied to participants who are screened [42].…”

“…With regard to screening and early detection, mention is made of people's positive acceptance of FOBT programmes [39]. In addition, screening coverage [33], information and awareness of the existence of the tests [40], participation rates [41] and having an intervention protocol in place [42] were key points when screening for the disease. However, a cross-sectional study by the Spanish National Health Survey (ENSE17) shows low participation in terms of screening coverage in the regions of Extremadura, Ceuta and Melilla, and Andalusia.…”