Improvements in antioxidant status after agraz consumption was associated to reductions in cardiovascular risk factors in women with metabolic syndrome

Abstract

In this study were evaluated the effects of the chronic consumption of agraz (Vaccinium meridionale) on antioxidant status and oxidative stress markers in 40 women with metabolic syndrome (MetS) (47.2 ± 9.4 years) through a double-blind, crossover design study, in which participants consumed daily agraz or placebo during 4 weeks, separated by a 4-wk washout period. At the end of each intervention period, endogenous antioxidant enzymes activity, serum total antioxidant capacity (TAC) (ferric reducing ability of plasma [FRAP]; Oxygen Radical Absorbance Capacity [ORAC] and 2,2ʹ-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) [ABTS]), and oxidative stress markers (Oxo-2ʹ-deoxyguanosine (8-OHdG) and F2-isoprostane) were determined. Women who increased endogenous antioxidant enzymes activity and serum TAC after agraz consumption, compared to placebo, significantly reduced oxidative stress markers, total cholesterol, LDL-cholesterol (LDL-c) levels, and waist circumference, demonstrating beneficial effects in the group of women in whom antioxidant parameters increased after agraz consumption, evidencing an individual variability in response to the beverage consumed. Mejoras en el estado antioxidante después del consumo de agraz se asociaron con reducciones en factores de riesgo cardiovascular en mujeres con síndrome metabólico RESUMEN En este estudio se evaluaron los efectos del consumo crónico de agraz (Vaccinium meridionale) sobre el estado antioxidante y los marcadores de estrés oxidativo en 40 mujeres con síndrome metabólico (SM) (47,2 ± 9,4 años) mediante un estudio de diseño cruzado, doble ciego, en el que los participantes consumieron diariamente agraz o placebo durante 4 semanas, separados por un período de lavado de 4 semanas. Al final de cada período de intervención se midió la actividad de las enzimas antioxidantes endógenas, la capacidad antioxidante total en suero (capacidad reductora férrica del plasma [FRAP]; la capacidad de absorbancia de radicales de oxígeno [ORAC] y 2,2ʹ-azino-bis (3-etilbenzotiazolina)-Ácido 6-sulfónico) [ABTS]) y marcadores de estrés oxidativo (Oxo-2ʹ-desoxiguanosina (8-OHdG) y F2-isoprostano). Las mujeres que aumentaron la actividad de las enzimas antioxidantes endógenas y la capacidad antioxidante total sérica después del consumo de agraz, en comparación con el placebo, redujeron significativamente los marcadores de estrés oxidativo, el colesterol total, los niveles de colesterol LDL (c-LDL) y el perímetro abdominal, demostrando efectos benéficos en el grupo de mujeres que aumentaron los parámetros antioxidantes luego del consumo de agraz, evidenciando una variabilidad individual en respuesta a la bebida consumida.

Effect of Dietary Berry Supplementation on Antioxidant Biomarkers in Adults with Cardiometabolic Risks: A Systematic Review of Clinical Trials

“…All included studies were randomized controlled trials—30 used a parallel design and 24 used a crossover designed. Overall, 37 studies measured the effects of berries in adults with features of MetS [ 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 ] ( Table 1 ) and 17 studies measured these same effects in adults with obesity or overweight [ 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , ...…”

“…The 37 studies measuring outcomes in adults with features of MetS included 14 different dietary berries. Overall, 21 studies assessed only oxidative stress biomarkers [ 28 , 30 , 31 , 32 , 34 , 36 , 37 , 38 , 40 , 42 , 43 , 45 , 48 , 50 , 51 , 53 , 54 , 56 , 58 , 59 , 60 , 61 ], 13 studies assessed both oxidative stress and antioxidant biomarkers [ 27 , 29 , 35 , 39 , 41 , 42 , 44 , 46 , 47 , 52 , 55 , 57 , 62 ], and 3 studies assessed only antioxidant biomarkers [ 33 , 49 , 63 ].…”

“…Overall, 21 studies assessed only oxidative stress biomarkers [28,[30][31][32]34,[36][37][38]40,42,43,45,48,50,51,53,54,56,[58][59][60][61], 13 studies assessed both oxidative stress and antioxidant biomarkers [27,29,35,39,41,42,44,46,47,52,55,57,62], and 3 studies assessed only antioxidant biomarkers [33,49,63].…”

Consumption of Eggs Alone or Enriched with Annatto (Bixa orellana L.) Does Not Increase Cardiovascular Risk in Healthy Adults—A Randomized Clinical Trial, the Eggant Study

“…Total energy (Kcal) and macronutrient intake (g) were estimated using a Colombian food database [ 28 ]. This FFQ has been validated in a similar population [ 29 ] and has been used in previous studies [ 30 , 31 ].…”