Improvement with Duloxetine in an Adult ADHD Patient

Tourjman, Smadar Valérie; Bilodeau, Mathieu

doi:10.1177/1087054708326109

Cited by 8 publications

(6 citation statements)

References 3 publications

(1 reference statement)

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“…The first study that showed the effect of duloxetine on ADHD was a case report administering 60 mg/day duloxetine to a 53-year-old man with a recent diagnosis of ADHD. The results demonstrated a significant reduction in the Conners scale (30). Duloxetine has recently been reported to be useful in reducing ADHD symptoms in a 16-year-old girl with ADHD.…”

Section: Discussionmentioning

confidence: 83%

Preliminary Investigation on Duloxetine Efficacy in the Treatment of Children With Attention-Deficit Hyperactivity Disorder

2015

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Background: Stimulants are first-line agents for the treatment of attention-deficit/hyperactivity disorder (ADHD). Despite the impressive track record of stimulants in the treatment of ADHD, they fail in 25% of patients due to lack of efficacy or the emergence of unwanted side effects. Objectives: In this study, we investigated the efficacy and safety of duloxetine, a serotonin and norepinephrine reuptake inhibitor, in the treatment of children with attention-deficit hyperactivity disorder (ADHD). Patients and Methods:In an open label clinical trial, 13 children aged 6 -11 years diagnosed with ADHD were prescribed 30 mg/day duloxetine once daily by oral administration for six weeks. Conners Parent Rating Scale-Revised-Short form (CPRS-R-S) and the ADHD Rating Scale were used to assess the efficacy of the treatment. Results: Ten children with a mean age of 8.40 ± 1.67 years terminated the trial. A significant reduction in CPRS-R and its subscales was evident from week four of the study. In terms of side effects, duloxetine was generally safe and well tolerated. Conclusions: This preliminary assessment suggests that duloxetine may be a medication of interest in the treatment of children with ADHD. Further controlled studies with larger samples are required to evaluate the efficacy of duloxetine in treatment of children with ADHD.

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Section: Discussionmentioning

confidence: 83%

Preliminary Investigation on Duloxetine Efficacy in the Treatment of Children With Attention-Deficit Hyperactivity Disorder

2015

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“…Additionally, duloxetine was not associated with any serious adverse effects. Improvements in ADHD symptoms have also been reported in an adult diagnosed with ADHD (Tourjman and Bilodeau, 2009). Tourjman and Bilodeau (2009) proposed duloxetine as a promising option in the treatment of adults with ADHD who do not respond to or develop side effects on the usual ADHD treatments.…”

Section: Discussionmentioning

confidence: 85%

Duloxetine in the treatment of adolescents with attention deficit/hyperactivity disorder: an open-label study

Mahmoudi-Gharaei

Dodangi

Tehrani‐Doost

et al. 2011

Hum. Psychopharmacol. Clin. Exp.

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“…In particular, glutamatergic and dopaminergic signaling in the cortico‐striatal pathway appears to be important for effects of hyperactivity in DAT KO mice (Gainetdinov et al, 2001). There are some cases of adults with ADHD responding positively to duloxetine, a selective serotonin–norepinephrine reuptake inhibitor (SSNRI) (Tourjman & Bilodeau, 2009). However, currently, few studies have explored the effectiveness of SSRIs and other antidepressants in ADHD (Verbeeck, Tuinier, & Bekkering, 2009).…”

Section: Attention Deficit Hyperactivity Disordermentioning

confidence: 99%

Annual Research Review: Transgenic mouse models of childhood‐onset psychiatric disorders

Robertson

Feng

2011

Child Psychology Psychiatry

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Childhood-onset psychiatric disorders, such as attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), mood disorders, obsessive compulsive spectrum disorders (OCSD), and schizophrenia (SZ), affect many school-age children, leading to a lower quality of life, including difficulties in school and personal relationships that persist into adulthood. Currently, the causes of these psychiatric disorders are poorly understood, resulting in difficulty diagnosing affected children, and insufficient treatment options. Family and twin studies implicate a genetic contribution for ADHD, ASD, mood disorders, OCSD, and SZ. Identification of candidate genes and chromosomal regions associated with a particular disorder provide targets for directed research, and understanding how these genes influence the disease state will provide valuable insights for improving the diagnosis and treatment of children with psychiatric disorders. Transgenic mouse models are one important approach in the study of human diseases, allowing for the use of a variety of experimental approaches to dissect the contribution of a specific chromosomal or genetic abnormality in human disorders. While it is impossible to model an entire psychiatric disorder in a single mouse model, these models can be extremely valuable in dissecting out the specific role of a gene, pathway, neuron subtype, or brain region in a particular abnormal behavior. In this review we discuss existing transgenic mouse models for childhood-onset psychiatric disorders. We compare the strength and weakness of various transgenic mouse models proposed for each of the common childhood-onset psychiatric disorders, and discuss future directions for the study of these disorders using cutting-edge genetic tools.

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Improvement with Duloxetine in an Adult ADHD Patient

Abstract: Duloxetine could be an option for patients who either do not tolerate or show resistance to more common pharmacological choices. Randomized controlled trials are needed to assess the efficacy of duloxetine in treating ADHD symptoms.

Cited by 8 publications

References 3 publications

Preliminary Investigation on Duloxetine Efficacy in the Treatment of Children With Attention-Deficit Hyperactivity Disorder

Preliminary Investigation on Duloxetine Efficacy in the Treatment of Children With Attention-Deficit Hyperactivity Disorder

Duloxetine in the treatment of adolescents with attention deficit/hyperactivity disorder: an open-label study

Annual Research Review: Transgenic mouse models of childhood‐onset psychiatric disorders

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