Improvement of wrinkles by an all-trans-retinoic acid derivative, d-δ-tocopheryl retinoate

Okano, Yasuaki; Obayashi, Kei; Yahagi, Syoichi; Kurihara, Kouji; Satoko, Kaburagi; Kurata, Yoshiko; Hashimoto, Masaki

doi:10.1016/j.descs.2006.08.008

Cited by 5 publications

(5 citation statements)

References 48 publications

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“…Past studies have shown that topical application of RA to human skin prevents UV radiation-induced activation of MMP-1, which is involved in the destruction of the extracellular matrix (Rosenthal et al, 1990). However, topical treatment with RA is often associated with irritation, the induction of epidermal changes similar to those produced by sodium lauryl sulphate and mutagenicity (Okano et al, 2006).…”

Section: Resultsmentioning

confidence: 99%

The effect of xanthorrhizol on the expression of matrix metalloproteinase‐1 and type‐I procollagen in ultraviolet‐irradiated human skin fibroblasts

Shim

Gwon

et al. 2009

Phytotherapy Research

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Matrix metalloproteinases (MMPs) are key regulators of the skin photoaging process that is set in motion by exposure to ultraviolet (UV) irradiation. This skin damage results from UV-induced generation of reactive oxygen species, which are associated with upregulation of MMPs and decreased collagen synthesis. We investigated the effects of xanthorrhizol, isolated from Curcuma xanthorrhiza, on the expression of MMP-1 and type-I procollagen in UV-irradiated human skin fibroblasts. Fibroblasts cultured in the presence or absence of purified xanthorrhizol or C. xanthorrhiza extract were irradiated with UV (20 mJ/cm(2)), and MMP-1 and type-I procollagen levels were measured using Western blot analysis. Xanthorrhizol (0.001-0.1 microM) and C. xanthorrhiza extract (0.01-0.5 microg/mL) induced a significant, dose-dependent decrease in the expression of MMP-1 protein, and increased the expression of type-1 procollagen. At a concentration of 0.1 microM, xanthorrhizol nearly completely abrogated MMP-1 expression. The MMP-1-suppressing and type-1 procollagen-inducing effects of xanthorrhizol treatment were greater than those of epigallocatechin 3-O-gallate (EGCG), which is known to be a natural anti-aging agent. These results suggest that xanthorrhizol is a potential candidate for the prevention and treatment of skin aging.

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Section: Resultsmentioning

confidence: 99%

The effect of xanthorrhizol on the expression of matrix metalloproteinase‐1 and type‐I procollagen in ultraviolet‐irradiated human skin fibroblasts

Shim

Gwon

et al. 2009

Phytotherapy Research

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“…A role of vitamin A in the synthesis of hyaluronic acid by skin cells has also been reported (7)(8)(9)(10)(11)(12)(13)(14). Hyaluronic acid is produced by corneal epithelial cells and keratocytes in the eye, and is known to be one of the factors that promotes the healing of corneal injuries.…”

mentioning

confidence: 99%

“…Hyaluronic acid is produced by corneal epithelial cells and keratocytes in the eye, and is known to be one of the factors that promotes the healing of corneal injuries. Accordingly, we investigated whether cultured rabbit corneal epithelial cells and keratocytes release hyaluronic acid after exposure to vitamin A compounds, as has been reported for epidermal keratinocytes in skin (7)(8)(9)(10)(11)(12)(13)(14).…”

mentioning

confidence: 99%

The Effects of Vitamin A Compounds on Hyaluronic Acid Released from Cultured Rabbit Corneal Epithelial Cells and Keratocytes

Toshida

Tabuchi

Koike

et al. 2012

J Nutr Sci Vitaminol

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Summary A role of vitamin A in the synthesis of hyaluronic acid by skin cells is well known. Hyaluronic acid is produced by corneal epithelial cells and keratocytes in the eye. We investigated whether rabbit corneal epithelial cells and keratocytes release hyaluronic acid after exposure to vitamin A compounds. Rabbit corneal epithelial cells and keratocytes were inoculated with RCGM2 medium and incubated at 37˚C under 5% CO2 in air for 24 h. The medium was then replaced with medium containing 0.1, 1, 10, or 100 M retinoic acid or retinol palmitate (VApal) and incubated for another 48 h. Hyaluronic acid release from both corneal epithelial cells and keratocytes during culture was increased by retinoic acid at the lower concentration of 0.1 M and 1 M determined with a sandwich binding protein assay kit. However, it was signifi cantly decreased at the higher concentrations of 10 M and 100 M, and the cell count determined with a Neutral Red assay kit was also decreased at these concentrations. On the other hand, hyaluronic acid release from corneal epithelial cells during culture was increased by VApal at the lower concentration of 0.1 M and 1 M, but there was no signifi cant difference in the cell count for either corneal epithelial cells or keratocytes in the presence of VApal at any concentration. In conclusion, it is suggested that vitamin A stimulates the release of hyaluronic acid from cultured rabbit corneal epithelial cells and keratocytes.

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“…The amount of the wrinkles on the skin substantially decreased, and the primary and secondary lines on the skin obviously recovered. Low molecular antioxidant substances were reported to protect effectively against oxidative stress that leads to photoageing [14]. In addition, it was reported that higher levels of antioxidants such as lycopene in the skin effectively result in lower levels of skin roughness [15].…”

Section: Resultsmentioning

confidence: 99%

Skin improvement and stability of Echinacea purpurea dermatological formulations

Yotsawimonwat

Rattanadechsakul

et al. 2010

Intern J of Cosmetic Sci

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Echinacea purpurea contains many beneficial constituents for protection of skin from oxidative stress and for improving hydration of skin. This study aimed to investigate the stability and dermatological efficacy of E. purpurea cream and gel. Echinacea purpurea extract was incorporated into suitable cream and gel bases. Stability of the extract in the formulations was investigated by determining its residual total phenolic content and antioxidant activity after storage at 4°C, 30°C and 40°C for 6 months. The effect of those formulations on skin irritation, hydration level and wrinkle reduction was evaluated in 10 healthy volunteers, aged 25-40 years. The shelf lives of E. purpurea cream and gel in terms of total phenolic content and antioxidant activity were only 2 and 4 months respectively at 4°C and could be extended up to 7 months by incorporation of α-tocopherol or disodium editate. The corneometer hydration indices increased up to 10.6 AU and 11.4 AU, and the wrinkles decreased 9.47% and 14.92% because of the application of E. purpurea cream and gel for 1 month. Both formulations showed no irritation to skin. Echinacea purpurea cream and gel developed in this study were effective in improving skin hydration and reducing wrinkle, but showed low storage stability.

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Improvement of wrinkles by an all-trans-retinoic acid derivative, d-δ-tocopheryl retinoate

Cited by 5 publications

References 48 publications

The effect of xanthorrhizol on the expression of matrix metalloproteinase‐1 and type‐I procollagen in ultraviolet‐irradiated human skin fibroblasts

The effect of xanthorrhizol on the expression of matrix metalloproteinase‐1 and type‐I procollagen in ultraviolet‐irradiated human skin fibroblasts

The Effects of Vitamin A Compounds on Hyaluronic Acid Released from Cultured Rabbit Corneal Epithelial Cells and Keratocytes

Skin improvement and stability of Echinacea purpurea dermatological formulations

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