Background:The post-COVID-19 condition is a group of durable physical, cognitive, and/or psychiatric symptoms that last for greater than 12 weeks following COVID-19. Until now, there has been no exact rehabilitation program for improving physical performance and oxygen saturation. Purpose: To compare the impacts of kinesiotape (KT) and diaphragmatic breathing exercises on physical performance and oxygen saturation. Methods: Sixty post-COVID-19 patients were allocated into three groups. Group A: 20 patients were given pursed-lip breathing and Cognitive Behavior Therapy (CBT) for 6 weeks. Group B: 20 patients were given diaphragmatic breathing exercises in addition to pursed-lip breathing and CBT for six weeks. Group C: 20 patients were given KT in addition to pursed-lip breathing and CBT for 6 weeks. Outcome measures included: Physical performance evaluated by a six-minute walk test (6MWT), and oxygen saturation measured by a pulse oximeter. The assessment was done at baseline and six weeks after treatment. Results: Three groups showed a statistically significant improvement in 6MWT and oxygen saturation after treatment compared to before treatment (p < 0.001). But group B had a significantly higher 6MWT and oxygen saturation in comparison with both group A and group C (p < 0.05). Conclusion: Diaphragmatic breathing exercises added to pursed-lip breathing and cognitive behavior therapy are more effective than KT in the rehabilitation of post-COVID-19 patients.