Improvement of Uremic Hypogeusia by Zinc

Marie, Suely Kazue Nagahashi; As, Prasad; Lambujon, Jesse; Aa, Abbasi; Wa, Briggs; Fd, McDonald

doi:10.1097/00002480-197902500-00085

Cited by 19 publications

(9 citation statements)

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“…In summary, the present study adds further support to the view that chronic uremia is a zinc-deficient or zinc-re sistant state [24,45,46], and it is therefore likely that a critical plasma concentration of zinc is essential for some of its biological effects. In addition, zinc binding to proteins may be altered in uremia with consequent reduc tion of ionized zinc which may be the most essential fraction.…”

Section: Discussionsupporting

confidence: 74%

Zinc-Induced Enhancement of Lymphocyte Function and Viability in Chronic Uremia

Antoniou¹,

Shalhoub²

1985

Nephron

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Spontaneous and phytohemagglutinin (PHA)-induced lymphocyte blastogenesis (LB) was measured by the incorporation of ³H-thymidine into lymphocytes from zinc-treated (group I) and non-zinc-treated (group II) patients on maintenance hemodialysis and from normal controls. The results were expressed as disintegrations per minute (dpm) per 200,000 cells. Spontaneous LB was comparable in the 3 groups. LB in response to PHA was impaired in group II (mean dpm 28,244 ± 13,499 SEM) as compared to group I (163,407 ± 14,325; p < 0.001) or controls (193,711 ± 9,406 ;p < 0.001). In 5 group II patients the mean dpm rose from (45,630 ± 26,334 SD to 211,795 ± 78,231; p < 0.025) after zinc therapy. The mean percentages of viable lymphocytes after 72 h of culture were 53.8,85.8 and 85.5 in groups II, I, and controls, respectively. These results clearly indicate that zinc therapy improves lymphocyte function and viability in uremia and suggest that abnormal zinc metabolism may play a role in the impaired cellular immunity in this disorder.

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Section: Discussionsupporting

confidence: 74%

Zinc-Induced Enhancement of Lymphocyte Function and Viability in Chronic Uremia

Antoniou¹,

Shalhoub²

1985

Nephron

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“…5,25,37 tory acuity has been observed in animals 53 and in humans in association with a number of disease states. [54][55][56][57] Zinc is In the present study, the mean serum magnesium concentration was significantly lower in the patient population than required for the synthesis and activity of the salivary protein gustin, which plays a role at taste bud receptor sites. 58 Howin healthy volunteers.…”

Section: Healthy Volunteers and 75 Cirrhotic Patientsmentioning

confidence: 61%

Taste perception in cirrhosis: Its relationship to circulating micronutrients and food preferences

1997

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in patients with dry mouths, e.g., those with primary biliary Impairment of gustatory acuity may influence nutrient incirrhosis and associated Sjö gren's syndrome. 10 Second, patake and hence nutritional status. The aim of this study was tients and healthy volunteers were not matched for certain to evaluate gustatory acuity in patients with cirrhosis and its factors known to affect gustatory function, such as smoking relationship to circulating concentrations of micronutrients, behavior 11,12 or denture wearing. 13 and food preferences. Gustatory evaluation was undertaken, Zinc and vitamin A are both important in maintaining taste using a rinsing technique, in 75 cirrhotic patients and 75 integrity, although their exact roles have not been elucicomparable healthy volunteers. Circulating concentrations of dated. 14 Although assessment of zinc status in humans is magnesium, zinc, vitamin A, and a-and b-carotene were meadifficult, zinc depletion is commonly reported in individuals sured, and food preferences were assessed by questionnaire.with cirrhosis. [15][16][17] However, no conclusive association has The cirrhotic patients showed impaired gustatory function been reported between zinc depletion and impaired gustatory with significantly higher (less sensitive) median thresholds function in patients with liver disease. 4,5,7,18,19 Indicators of for detection of salt, sweet, and sour and for recognition of vitamin A status are also reduced in this patient populabitter, salt, sweet, and sour, together with a higher overall tion, 20,21 and there is evidence that vitamin A supplementamedian gustatory score (P õ .0001). Mean circulating concention may improve gustatory function in cirrhotic patients trations of magnesium, zinc, vitamin A, and a-and b-carotene who are vitamin A-depleted. 6 Magnesium deficiency has were significantly lower in the patient population. Serum magbeen documented in patients with cirrhosis, 22 and although nesium was significantly negatively associated with detection it has not previously been associated with taste integrity, of salt (P Å .02) and gustatory score (P Å .02). Patients' the anorexia commonly observed in cirrhotic patients may subjective assessment of taste acuity did not correspond with resolve after magnesium supplementation. 23 objective measurements. Overall, no differences were obThere is little information on the relationship between imserved in food preferences between the two groups, nor was paired taste perception and alterations in food selection and any association found between food preferences and gustatory eating habits, although it is reasonable to suppose that they acuity. Patients with cirrhosis have impaired gustatory acuity may be interrelated. 8,24 Aversions to fatty foods, meat, and that is associated with hypomagnesemia but apparently does fried dishes and a preference for citrus fruits have been renot affect food selection. (HEPATOLOGY 1997;26:40-48.) ported in patients with liver disease, 8,25,26 although gustatory acuity was not formally tested in any of ...

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“…Zinc deficiency is known to affect appetite and eating behavior (50). Several studies found that zinc deficiency is associated with an altered sense of taste and decreased taste acuity that can be reversed by zinc supplementation (51)(52)(53). Underlying zinc deficiency could be altering the adolescentsÕ taste perception and, therefore, could be related to their pica behaviors.…”

Section: Discussionmentioning

confidence: 99%

Gestational Iron Deficiency Is Associated with Pica Behaviors in Adolescents

Lumish

Young

Lee

et al. 2014

The Journal of Nutrition

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A relation between pica (the craving and purposive consumption of nonfood items) during pregnancy and anemia is observed frequently. However, few studies related pica behaviors to biomarkers of iron status, and little is known about pica prevalence in U.S. pregnant adolescents. To address this, we undertook a longitudinal study examining iron status and pica behaviors among a group of 158 pregnant adolescents (aged ≤18 y). Approximately two-thirds of the participants were African American and 25% were Hispanic. Maternal iron status indicators [hemoglobin, soluble transferrin receptor, serum ferritin (SF), total body iron (TBI), and serum hepcidin] were assessed during pregnancy (18.5-37.3 wk) and at delivery. Pica behavior was assessed up to 3 times across gestation. Among the 158 adolescents, 46% reported engaging in pica behavior. Substances ingested included ice (37%), starches (8%), powders (4%), and soap (3%). During pregnancy, mean SF [geometric mean: 13.6 μg/L (95% CI: 11.0, 17.0 μg/L)], TBI (mean ± SD: 2.5 ± 4.2 mg/kg), and hepcidin [geometric mean: 19.1 μg/L (95% CI: 16.3, 22.2 μg/L)] concentrations were significantly lower (P < 0.05) in the pica group (n = 72) than values observed among the non-pica group [SF, geometric mean: 21.1 μg/L (95% CI: 18.0, 25.0 μg/L); TBI, mean ± SD: 4.3 ± 3.5 mg/kg; hepcidin, geometric mean: 27.1 μg/L (95%: 23.1, 32.1 μg/L); n = 86]. Although additional studies must address the etiology of these relations, this practice should be screened for, given its association with low iron status and because many of the substances ingested may be harmful. This trial was registered at clinicaltrials.gov as NCT01019902.

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Improvement of Uremic Hypogeusia by Zinc

Cited by 19 publications

References 0 publications

Zinc-Induced Enhancement of Lymphocyte Function and Viability in Chronic Uremia

Zinc-Induced Enhancement of Lymphocyte Function and Viability in Chronic Uremia

Taste perception in cirrhosis: Its relationship to circulating micronutrients and food preferences

Gestational Iron Deficiency Is Associated with Pica Behaviors in Adolescents

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