Improvement of the visual field index in clinical glaucoma care

Cohen, Shawn L.; Rosen, Aaron; Tan, Xianming; Kingdom, Frederick A. A.

doi:10.1016/j.jcjo.2016.10.001

Cited by 5 publications

(4 citation statements)

References 12 publications

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“…The converse observation that a small number of cases of uveitic glaucoma developed improvement in cup-to-disc ratio and MD is somewhat unexpected, although some similar reports exist showing this pattern occurring in some cases with open angle glaucoma. 26 Our sample size is not sufficient other than to provide preliminary data regarding the issue of potential improvements, predictive factors for improvement, and indeed whether such observations are robust over long periods of time. However, the cases reported did show sustained improvement across semi-annual or annual visits.…”

Section: Discussionmentioning

confidence: 92%

Incidence and Outcome of Uveitic Glaucoma in Eyes With Intermediate, Posterior, or Panuveitis Followed up to 10 Years After Randomization to Fluocinolone Acetonide Implant or Systemic Therapy

Kempen

Natta

Friedman

et al. 2020

American Journal of Ophthalmology

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Section: Discussionmentioning

confidence: 92%

Incidence and Outcome of Uveitic Glaucoma in Eyes With Intermediate, Posterior, or Panuveitis Followed up to 10 Years After Randomization to Fluocinolone Acetonide Implant or Systemic Therapy

Kempen

Natta

Friedman

et al. 2020

American Journal of Ophthalmology

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“…Recently published findings reported that VF data can undergo both short- and long-term improvement after medical or surgical intervention. 5 , 31 – 34 We have included the possibility of improvement in our method by applying an exponential fit to VF test locations with an a priori improving trend. An inverted exponential decay fit with a ceiling asymptote of the age-matched normal +2 SD value was applied, as opposed to applying a constant multiplicative (linear) rate of improvement to a longitudinal VF series, which seems to not be physiologically appropriate.…”

Section: Discussionmentioning

confidence: 99%

A Method to Measure the Rate of Glaucomatous Visual Field Change

Mohamed

Morales

Rabiolo

et al. 2018

Trans. Vis. Sci. Tech.

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PurposeTo develop a method to measure the rate of glaucomatous visual field (VF) deterioration and to identify fast progressors.MethodsRetrospective, longitudinal, observational study of 8486 eyes of 4610 glaucomatous patients with ≥6 VFs and ≥3 years of follow-up. A Glaucoma Rate Index (GRI) was calculated. VF locations were partitioned into exponential decay or exponential improvement models. A pointwise rate of change (PRC) was estimated with an exponential fit and expressed as the percent/year change of the age- and location-matched normal perimetric range, presented as a spatially conserved VF map. PRCs were summed and normalized with boundary rates set by simulated decaying and improving VF series on a scale of −100 to +100, respectively.ResultsA total of 89,704 VF examinations with 425,039 test location series was used. Median follow-up and number of VFs/eye were 9.7 years and 9 VFs, respectively. Initial and final mean deviations (±SD) were −4.2 (±5.2) and −5.7 (±6.4) dB. The proportions of test locations designated as decayed, improved, and unchanged were 13%, 4%, and 83%, respectively. Mean PRCs for decay, improvement, and no change were −3.7 (±4.7)%/y, 2.5 (±2.6)%/y, and −0.5 (±2.1)%/y, respectively. The number of eyes with negative and positive GRIs was 5802 (68%) and 2390 eyes (28%), respectively. The proportion of eyes defined as fast progressors was 6.8%.ConclusionsGRI provides a robust measure of glaucomatous VF change, operates without discontinuity over the entire perimetric range, and can be used to identify fast progressors.Translational RelevanceThis study describes a novel method that can help the clinician to determine VF progression.

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“…Studies have shown that eye surgeries, including intraocular pressure-lowering surgeries, 26–29 cataract extraction, 30,31 and ranibizumab treatment, 32,33 can lead to enhanced VF sensitivity, which may trigger GHT results reversals. For our 97 eyes, we did not find any significant effects of eye surgeries on GHT results reversals (Table S2, available at www.aaojournal.org).…”

Section: Discussionmentioning

confidence: 99%