Improvement of the Pupillary Light Reflex of Royal College of Surgeons Rats Following RPE Cell Grafts

Whiteley, Simon J.O.; Litchfield, T.M.; Coffey, Peter; Lund, Raymond D.

doi:10.1006/exnr.1996.0120

Cited by 54 publications

(19 citation statements)

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“…This mutation results in profound photoreceptor loss occurring over a severalmonth time period (2,3). Degeneration can be slowed by subretinal injection of normal RPE cells, derived either from allogeneic or xenogeneic sources (4)(5)(6)(7)(8)(9). These results have led to similar transplantation studies in humans with age-related macular degeneration, albeit without success so far (10)(11)(12).…”

mentioning

confidence: 54%

Subretinal transplantation of genetically modified human cell lines attenuates loss of visual function in dystrophic rats

Lund

Adamson

Sauvé

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

179

118

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mentioning

confidence: 54%

Subretinal transplantation of genetically modified human cell lines attenuates loss of visual function in dystrophic rats

Lund

Adamson

Sauvé

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

179

118

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“…The majority of photoreceptors degen erate during the first 3 months of life [35], but there is a slower rate of photoreceptor loss occurring over a prolonged time frame [36]. Transplantation of healthy RPE during the first month of life delays the degenerative pro cess [37],…”

Section: Introductionmentioning

confidence: 99%

Intraretinal Transplantation to Prevent Photoreceptor Degeneration

et al. 1997

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There is great interest in the potential of transplantation to treat retinal degenerative diseases in humans; however, there are still fundamental questions to be addressed in experimental animal studies. We have concentrated on two of these using the Royal College of Surgeons (RCS) rat as a suitable animal model. Firstly, does the loss of photoreceptors lead to secondary changes in the inner retina, which might compromise any photoreceptor preservation strategy? Analysis has shown that there are not only histochemical changes in the inner plexiform layer but also degeneration of retinal ganglion cells. The latter, occurring as a result of a vascular event, appears to have a parallel in some human retinal degenerative diseases. Secondly, what are the functional implications of the progressive photoreceptor loss in the RCS rat and how may transplantation prevent or slow that process? A progressively enlarging visual field defect can be demonstrated in these rats which can be stabilized by transplantation of retinal pigment epithelial cells. There is also a loss or diminished performance in a variety of visual tasks, although the rate of deterioration depends on the task; this too can be limited by cell transplantation. Current results indicate an optimistic future for transplantation in human retinal degenerative disease, but also emphasize the many preparatory steps that still have to be made for a successful clinical outcome.

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“…The RCS rat is a widely used animal model of inherited retinal dystrophy in which the disability of RPE phagocytosis of shed outer segments by a mutation in the gene encoding the receptor tyrosine kinase Mertk leads to progressive loss of photoreceptors (D'Cruz et al, 2000;Feng et al, 2002). The restoration of visual function in RPE cell transplanted RCS rats was confirmed using ERG, pupillary reflex, and recording receptive fields across the surface of the superior colliculus (Yamamoto et al, 1993;Whiteley et al, 1996;Sauve et al, 1998;Coffey et al, 2002).…”

Section: Rpe Transplantationmentioning

confidence: 99%

Stem cell biology and cell transplantation therapy in the retina

Osakada

Hirami²,

Takahashi³

2009

Biotechnology and Genetic Engineering Reviews

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Embryonic stem (ES) cells, which are derived from the inner cell mass of mammalian blastocyst stage embryos, have the ability to differentiate into any cell type in the body and to grow indefinitely while maintaining pluripotency. During development, cells undergo progressive and irreversible differentiation into specialized adult cell types. Remarkably, in spite of this restriction in potential, adult somatic cells can be reprogrammed and returned to the naive state of pluripotency found in the early embryo simply by forcing expression of a defined set of transcription factors. These induced pluripotent stem (iPS) cells are molecularly and functionally equivalent to ES cells and provide powerful in vitro models for development, disease, and drug screening, as well as material for cell replacement therapy. Since functional impairment results from cell loss in most central nervous system (CNS) diseases, recovery of lost cells

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Improvement of the Pupillary Light Reflex of Royal College of Surgeons Rats Following RPE Cell Grafts

Cited by 54 publications

References 0 publications

Subretinal transplantation of genetically modified human cell lines attenuates loss of visual function in dystrophic rats

Subretinal transplantation of genetically modified human cell lines attenuates loss of visual function in dystrophic rats

Intraretinal Transplantation to Prevent Photoreceptor Degeneration

Stem cell biology and cell transplantation therapy in the retina

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