Improvement of the pharmacokinetic/pharmacodynamic relationship in the treatment of invasive aspergillosis with voriconazole. Reduced drug toxicity through novel rapid release formulations

Gallego-Arranz, Teresa; Pérez-Cantero, Alba; Torrado-Salmerón, Carlos; Guarnizo-Herrero, Víctor; Capilla, Javier; Torrado-Durán, Santiago

doi:10.1016/j.colsurfb.2020.111119

Cited by 3 publications

(9 citation statements)

References 37 publications

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“…However, there were no improvements in the dissolution profile of SD-ATV (1:1.5 and 1:3) with high proportions of croscarmellose compared to SD-ATV (1:1). These changes in lipophilic drugs such as voriconazole have been studied previously [ 10 ]. The delayed dissolution profiles for SD-ATV (1:1.5) and SD-ATV (1:3) were related to a partial recrystallization of the croscarmellose.…”

Section: Resultsmentioning

confidence: 99%

“…To improve the poor solubility of EZ, surfactants such as Kolliphor RH40 have been used in micellar systems [ 7 ], while hydrophilic cellulose polymers such as Hydroxypropyl cellulose (HPC) or sodium croscarmellose have been selected for their pronounced hydrophilic properties [ 8 , 9 ] for the elaboration of solid dispersions of ATV, although EZ and ATV are difficult to quantify due to their low concentrations in liver tissue, meaning that the hepatic biodistribution of these active ingredients cannot be analyzed. Recent studies on other hydrophobic drugs such as voriconazole and amphotericin B showed a high liver biodistribution with similar micellar systems [ 10 ]. These active ingredients have shown an enterohepatic circulation, and the changes in the enterohepatic circulation of these drugs could be analyzed with an efficacy study in vivo in order to compare the differences between the formulations administered [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Multiparticulate Systems of Ezetimibe Micellar System and Atorvastatin Solid Dispersion Efficacy of Low-Dose Ezetimibe/Atorvastatin on High-Fat Diet-Induced Hyperlipidemia and Hepatic Steatosis in Diabetic Rats

et al. 2021

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The aim of this study was to develop multiparticulate systems with a combination of ezetimibe micellar systems and atorvastatin solid dispersions using croscarmellose as a hydrophilic vehicle and Kolliphor RH40 as a surfactant. The presence of a surfactant with low hydrophilic polymer ratios produces the rapid dissolution of ezetimibe through a drug–polymer interaction that reduces its crystallinity. The solid dispersion of atorvastatin with low proportions of croscarmellose showed drug–polymer interactions sufficient to produce the fast dissolution of atorvastatin. Efficacy studies were performed in diabetic Goto-Kakizaki rats with induced hyperlipidemia. The administration of multiparticulate systems of ezetimibe and atorvastatin at low (2 and 6.7 mg/kg) and high (3 and 10 mg/kg) doses showed similar improvements in levels of cholesterol, triglycerides, lipoproteins, alanine transaminase, and aspartate transaminase compared to the high-fat diet group. Multiparticulate systems at low doses (2 and 6.7 mg/kg of ezetimibe and atorvastatin) had a similar improvement in hepatic steatosis compared to the administration of ezetimibe and atorvastatin raw materials at high doses (3 and 10 mg/kg). These results confirm the effectiveness of solid dispersions with low doses of ezetimibe and atorvastatin to reduce high lipid levels and hepatic steatosis in diabetic rats fed a high-fat diet.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multiparticulate Systems of Ezetimibe Micellar System and Atorvastatin Solid Dispersion Efficacy of Low-Dose Ezetimibe/Atorvastatin on High-Fat Diet-Induced Hyperlipidemia and Hepatic Steatosis in Diabetic Rats

et al. 2021

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“…This technique is based on the dispersion of poorly water-soluble drugs into a hydrophilic carrier, creating a dispersed state with improved solubility [ 12 ]. Solvent evaporation methods [ 13 , 14 ], spray drying methods [ 9 ], fusion [ 15 ], and fusion/extrusion [ 16 ] have been commonly employed for the production of solid dispersions. In many cases, the solubility increase for these systems was related to the crystallinity decrease by the inclusion of drug molecules within the carrier chains [ 14 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…Solvent evaporation methods [ 13 , 14 ], spray drying methods [ 9 ], fusion [ 15 ], and fusion/extrusion [ 16 ] have been commonly employed for the production of solid dispersions. In many cases, the solubility increase for these systems was related to the crystallinity decrease by the inclusion of drug molecules within the carrier chains [ 14 , 17 ]. Solid dispersions with different antifungal active ingredients, such as NYS, voriconazole, or amphotericin B, have been designed to improve their solubility [ 9 , 10 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…An increased efficacy against biofilm communities was observed with the osmotic effect of polyethylene glycol in antibiotic treatments, such as tobramycin, chloramphenicol [ 24 ], and NYS [ 10 ]. Voriconazole or clotrimazole solid dispersions with sugars such as mannitol, fructose, or dextrose showed an increased antifungal effect [ 14 , 15 ]. Furthermore, maltodextrin (MD), a hyperosmotic carrier, was studied with antifungals such as vancomycin or amphotericin B [ 21 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

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Development of a Solid Dispersion of Nystatin with Maltodextrin as a Carrier Agent: Improvements in Antifungal Efficacy against Candida spp. Biofilm Infections

2021

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The aim of this study was to improve the treatment of Candida albicans biofilms through the use of nystatin solid dispersions developed using maltodextrins as a hyperosmotic carrier. Characterization studies by differential scanning calorimetry, X-ray diffraction, dissolution studies, and particle size analysis were performed to evaluate changes in nystatin crystallinity. Antifungal activity and anti-biofilm efficacy were assessed by microbiological techniques. The results for nystatin solid dispersions showed that the enhancement of antifungal activity may be related to the high proportions of maltodextrins. Anti-biofilm assays showed a significant reduction (more than 80%) on biofilm formation with SD-N:MD [1:6] compared to the nystatin reference suspension. The elaboration process and physicochemical properties of SD-N:MD [1:6] could be a promising strategy for treatment of Candida biofilms.

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Tumor Microenvironment-Responsive Drug Delivery Based on Polymeric Micelles for Precision Cancer Therapy: Strategies and Prospects

Jin,

Al Amili,

Guo

2024

Biomedicines

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In clinical practice, drug therapy for cancer is still limited by its inefficiency and high toxicity. For precision therapy, various drug delivery systems, including polymeric micelles self-assembled from amphiphilic polymeric materials, have been developed to achieve tumor-targeting drug delivery. Considering the characteristics of the pathophysiological environment at the drug target site, the design, synthesis, or modification of environmentally responsive polymeric materials has become a crucial strategy for drug-targeted delivery. In comparison to the normal physiological environment, tumors possess a unique microenvironment, characterized by a low pH, high reactive oxygen species concentration, hypoxia, and distinct enzyme systems, providing various stimuli for the environmentally responsive design of polymeric micelles. Polymeric micelles with tumor microenvironment (TME)-responsive characteristics have shown significant improvement in precision therapy for cancer treatment. This review mainly outlines the most promising strategies available for exploiting the tumor microenvironment to construct internal stimulus-responsive drug delivery micelles that target tumors and achieve enhanced antitumor efficacy. In addition, the prospects of TME-responsive polymeric micelles for gene therapy and immunotherapy, the most popular current cancer treatments, are also discussed. TME-responsive drug delivery via polymeric micelles will be an efficient and robust approach for developing clinical cancer therapies in the future.

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Improvement of the pharmacokinetic/pharmacodynamic relationship in the treatment of invasive aspergillosis with voriconazole. Reduced drug toxicity through novel rapid release formulations

Cited by 3 publications

References 37 publications

Multiparticulate Systems of Ezetimibe Micellar System and Atorvastatin Solid Dispersion Efficacy of Low-Dose Ezetimibe/Atorvastatin on High-Fat Diet-Induced Hyperlipidemia and Hepatic Steatosis in Diabetic Rats

Multiparticulate Systems of Ezetimibe Micellar System and Atorvastatin Solid Dispersion Efficacy of Low-Dose Ezetimibe/Atorvastatin on High-Fat Diet-Induced Hyperlipidemia and Hepatic Steatosis in Diabetic Rats

Development of a Solid Dispersion of Nystatin with Maltodextrin as a Carrier Agent: Improvements in Antifungal Efficacy against Candida spp. Biofilm Infections

Tumor Microenvironment-Responsive Drug Delivery Based on Polymeric Micelles for Precision Cancer Therapy: Strategies and Prospects

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