Improvement of the Oral Bioavailability of Digitalis Glycosides by CyclodextrinComplexation

Enhancement of Diosgenin Distribution in the Skin by Cyclodextrin Complexation Following Oral Administration

“…Inclusion complexation of a number of drugs with β-CD has been reported. [12][13][14] In the present study, we prepared and characterized complexes of diosgenin with several CDs. The effects of prepared CD inclusion complexes in the oral administration of diosgenin were investigated on skin content and oral bioavailability of diosgenin.…”

Design and Evaluation of Cyclodextrin-Based Drug Formulation

“…The possible enhancing mechanisms of CyDs on the bioavailability of drugs in various administration routes are summarized as follows: 1) hydrophilic CyDs increase the solubility, dissolution rate, and wettability of poorly watersoluble drugs, [82][83][84][85][86][87][88][89][90][91][92][93][94][95][96][97][98][99][100][101] 2) CyDs prevent the degradation or disposition of chemically unstable drugs in gastrointestinal tracts as well as during storage, [102][103][104][105][106][107][108][109][110][111] 3) CyDs perturb the membrane fluidity to lower the barrier function, which consequently enhances the absorption of drugs including peptide and protein drugs through the nasal and rectal mucosa, [112][113][114][115][116][117][118][119][120][121] 4) competitive inclusion complexation with third components (bile acid, cholesterol, lipids, etc.) to release the included drug, [122][123][124][1...…”

Facile Preparation and Extensive Characterization of Naproxen–β-Cyclodextrin Inclusion Complex

“…It can increase the stability of drugs and avoid the influence of heat, light, air, and chemical environment. It also can enhance the bio-availability and lower the toxic and side effect of such compounds [15][16][17][18][19]. Besides, applications further include the ability to solidify the liquid medicine and the reduction of unwanted tastes and odor.…”