Abstract:Human induced pluripotent stem (hiPS) cells are a powerful tool for biomedical research. The ability to create patient-specific pluripotent cells and their subsequent differentiation into any somatic cell type makes hiPS cells a valuable object for creating in vitro models of human diseases, screening drugs and a future source of cells for regenerative medicine. To realize entirely a potential of hiPScells, effective and precise methods for their genome editing are needed. The CRISPR/Cas9 system is the most wi… Show more
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